Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/MazF(toxin)
Location 4131636..4132278 Replicon chromosome
Accession NZ_CP099450
Organism Bacillus pacificus strain ANSB901

Toxin (Protein)


Gene name pemK Uniprot ID J8CWW5
Locus tag NE411_RS21755 Protein ID WP_000635963.1
Coordinates 4131928..4132278 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID R8I8H2
Locus tag NE411_RS21750 Protein ID WP_000004570.1
Coordinates 4131636..4131923 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE411_RS21725 (NE411_21680) 4126962..4127924 + 963 WP_000961156.1 UV DNA damage repair endonuclease UvsE -
NE411_RS21730 (NE411_21685) 4127917..4128489 - 573 WP_000907063.1 rhomboid family intramembrane serine protease -
NE411_RS21735 (NE411_21690) 4128582..4128941 + 360 WP_000635037.1 holo-ACP synthase -
NE411_RS21740 (NE411_21695) 4129098..4130048 + 951 WP_029141035.1 outer membrane lipoprotein carrier protein LolA -
NE411_RS21745 (NE411_21700) 4130167..4131336 + 1170 WP_000390608.1 alanine racemase -
NE411_RS21750 (NE411_21705) 4131636..4131923 + 288 WP_000004570.1 antitoxin EndoAI Antitoxin
NE411_RS21755 (NE411_21710) 4131928..4132278 + 351 WP_000635963.1 type II toxin-antitoxin system endoribonuclease NdoA Toxin
NE411_RS21760 (NE411_21715) 4132346..4134514 + 2169 WP_000426205.1 Tex family protein -
NE411_RS21765 (NE411_21720) 4134572..4134688 - 117 WP_001143642.1 cortex morphogenetic protein CmpA -
NE411_RS21770 (NE411_21725) 4134884..4135342 + 459 WP_000344243.1 SprT family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(1-113)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12974.12 Da        Isoelectric Point: 5.7168

>T248909 WP_000635963.1 NZ_CP099450:4131928-4132278 [Bacillus pacificus]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTVIVAAITAQIQKAKLPTHVEIDAKKYGFERDSVILLEQI
RTIDKQRLTDKITHLDEVMMIRVDEALQISLGLIDF

Download         Length: 351 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10780.36 Da        Isoelectric Point: 8.9605

>AT248909 WP_000004570.1 NZ_CP099450:4131636-4131923 [Bacillus pacificus]
VSESSVTTEIVVRLPKQMVTELDGIGKQENKNRHELICQATQLLLRQHKTKKRYQHESMRRGYIEMGKINLGIASEAFLA
EYEAAHTVERLVSGG

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4HKE
PDB 7BXY

Antitoxin

Source ID Structure
AlphaFold DB A0A366FY90

References