Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /RES-TIGR02293
Location 103843..104753 Replicon plasmid pSKLX33367_VIR
Accession NZ_CP099414
Organism Klebsiella pneumoniae strain 33367

Toxin (Protein)


Gene name - Uniprot ID A0A663AYG0
Locus tag NE847_RS27570 Protein ID WP_004026354.1
Coordinates 103843..104313 (-) Length 157 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A6P1V3Q9
Locus tag NE847_RS27575 Protein ID WP_004026357.1
Coordinates 104310..104753 (-) Length 148 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE847_RS27545 (NE847_27545) 99255..99653 - 399 WP_004212796.1 H-NS family nucleoid-associated regulatory protein -
NE847_RS27550 (NE847_27550) 99990..100484 - 495 WP_004212794.1 thermonuclease family protein -
NE847_RS27555 (NE847_27555) 100662..100928 + 267 WP_223175074.1 DUF1173 family protein -
NE847_RS27560 (NE847_27560) 100961..101611 + 651 WP_068893702.1 DUF1173 family protein -
NE847_RS27570 (NE847_27570) 103843..104313 - 471 WP_004026354.1 RES family NAD+ phosphorylase Toxin
NE847_RS27575 (NE847_27575) 104310..104753 - 444 WP_004026357.1 DUF2384 domain-containing protein Antitoxin
NE847_RS27580 (NE847_27580) 104854..105357 - 504 Protein_110 DUF4113 domain-containing protein -
NE847_RS27585 (NE847_27585) 105563..106543 - 981 WP_000019473.1 IS5-like element ISKpn26 family transposase -
NE847_RS27590 (NE847_27590) 106609..107916 + 1308 Protein_112 FepA family TonB-dependent siderophore receptor -
NE847_RS27595 (NE847_27595) 107978..108199 + 222 WP_004213615.1 hypothetical protein -
NE847_RS27600 (NE847_27600) 108342..109244 - 903 WP_004213613.1 DMT family inner membrane transporter PEG344 -
NE847_RS27605 (NE847_27605) 109317..109718 - 402 WP_214588034.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Mobilizable plasmid - iroN / rmpA / iucA / iucB / iucC / iucD / iutA / rmpA2 1..215836 215836
- inside IScluster/Tn - - 97804..106543 8739


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

RES domain

(3-148)

Antitoxin

Antitoxin Xre-like, helix-turn-helix domain

(30-89)


Sequences

Toxin        


Download         Length: 157 a.a.        Molecular weight: 17515.79 Da        Isoelectric Point: 4.6155

>T248900 WP_004026354.1 NZ_CP099414:c104313-103843 [Klebsiella pneumoniae]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPGNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK

Download         Length: 471 bp

Antitoxin


Download         Length: 148 a.a.        Molecular weight: 16480.80 Da        Isoelectric Point: 10.2498

>AT248900 WP_004026357.1 NZ_CP099414:c104753-104310 [Klebsiella pneumoniae]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS

Download         Length: 444 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A663AYG0

Antitoxin

Source ID Structure
AlphaFold DB A0A6P1V3Q9

References