Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 463565..464307 Replicon chromosome
Accession NC_014500
Organism Dickeya dadantii 3937

Toxin (Protein)


Gene name ataT Uniprot ID E0SIC1
Locus tag DDA3937_RS02060 Protein ID WP_013316117.1
Coordinates 463565..464044 (-) Length 160 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID E0SJ01
Locus tag DDA3937_RS02065 Protein ID WP_013316118.1
Coordinates 464035..464307 (-) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DDA3937_RS02035 (Dda3937_01305) 459416..459616 + 201 WP_026357784.1 AlpA family transcriptional regulator -
DDA3937_RS02040 (Dda3937_01306) 459613..460152 + 540 WP_013316111.1 ash family protein -
DDA3937_RS02045 (Dda3937_01307) 460145..462190 + 2046 WP_013316112.1 AAA family ATPase -
DDA3937_RS02050 (Dda3937_01308) 462414..462680 - 267 WP_013316114.1 helix-turn-helix domain-containing protein -
DDA3937_RS02055 (Dda3937_01310) 463135..463536 - 402 WP_013316116.1 hypothetical protein -
DDA3937_RS02060 (Dda3937_01311) 463565..464044 - 480 WP_013316117.1 GNAT family N-acetyltransferase Toxin
DDA3937_RS02065 (Dda3937_01312) 464035..464307 - 273 WP_013316118.1 DUF1778 domain-containing protein Antitoxin
DDA3937_RS02070 (Dda3937_01313) 464868..465587 - 720 WP_081441324.1 methyltransferase domain-containing protein -
DDA3937_RS02075 (Dda3937_01314) 465598..465855 - 258 WP_013316120.1 YjhX family toxin -
DDA3937_RS02080 (Dda3937_01315) 466300..466638 - 339 WP_033111549.1 hypothetical protein -
DDA3937_RS02085 (Dda3937_01316) 467110..467913 + 804 WP_033111550.1 hypothetical protein -
DDA3937_RS02090 (Dda3937_01317) 468107..468589 - 483 WP_013316124.1 Lrp/AsnC family transcriptional regulator -
DDA3937_RS02095 (Dda3937_01318) 468753..469127 + 375 WP_033111551.1 Dabb family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(28-147)

Antitoxin

Vibrio phage ICP1, Orf50

(10-85)


Sequences

Toxin        


Download         Length: 160 a.a.        Molecular weight: 17564.34 Da        Isoelectric Point: 9.5367

>T24890 WP_013316117.1 NC_014500:c464044-463565 [Dickeya dadantii 3937]
VGITAPELLLPQHAVVDFHCSEPSLNEWLKRKALKNQTLGASRTFVVCEAGTQRVVGFYALASGSIQRQVAPGAFRRNMP
DPIPVLVLGRLAVDERYQRMGIGAGLLKDAVLRSRNVAQQVGNKALLVHALSDEAKAFYQYWGFVPSEIQEHTLLLSLW

Download         Length: 480 bp

>T24890 NC_014500:c464044-463565 [Dickeya dadantii 3937]
GTGGGAATAACGGCACCTGAATTATTGCTGCCTCAACATGCAGTTGTGGATTTTCATTGTTCCGAGCCGTCATTGAATGA
ATGGCTGAAACGCAAAGCGTTAAAAAATCAGACGCTGGGCGCTTCACGCACCTTCGTGGTGTGTGAAGCCGGTACACAGC
GTGTGGTGGGATTCTATGCCCTCGCGTCGGGTAGCATCCAGCGTCAGGTTGCGCCGGGCGCATTCCGGCGCAATATGCCT
GACCCCATTCCTGTTCTGGTACTTGGCCGATTAGCCGTTGATGAACGTTATCAACGCATGGGGATCGGCGCCGGACTTCT
GAAAGATGCGGTACTCCGCTCCCGCAATGTAGCGCAGCAGGTAGGCAACAAAGCGTTATTGGTACATGCGTTATCTGATG
AGGCAAAAGCGTTCTACCAATACTGGGGTTTTGTCCCGTCAGAAATACAGGAACACACCTTATTATTATCGTTATGGTAA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10384.88 Da        Isoelectric Point: 4.6702

>AT24890 WP_013316118.1 NC_014500:c464307-464035 [Dickeya dadantii 3937]
MRTEPKEMPINIRAKASQRELIDVAAKLLSKSRTEFILDAACREAEDVLLDQRLFLVNDEQYDAFIQVLESPVTDNPRVN
ALLNRKSPWE

Download         Length: 273 bp

>AT24890 NC_014500:c464307-464035 [Dickeya dadantii 3937]
ATGCGAACAGAGCCAAAAGAAATGCCGATTAATATTCGTGCTAAAGCATCACAGCGGGAGCTGATTGATGTCGCCGCTAA
ATTGCTGTCGAAATCAAGAACAGAGTTTATCCTTGATGCTGCCTGCCGTGAGGCTGAGGATGTGTTGTTGGATCAACGGC
TGTTTCTGGTCAATGATGAACAATATGATGCTTTCATTCAGGTGCTGGAATCACCTGTCACAGATAATCCGCGTGTGAAT
GCGTTACTGAACAGGAAATCTCCGTGGGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N0G158

Antitoxin

Source ID Structure
AlphaFold DB E0SJ01

References