Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mosAT/AbiEii-AbiEi
Location 5068848..5070529 Replicon chromosome
Accession NZ_CP099413
Organism Klebsiella pneumoniae strain 33367

Toxin (Protein)


Gene name mosT Uniprot ID W8V1Q6
Locus tag NE847_RS25160 Protein ID WP_002885155.1
Coordinates 5068848..5069765 (-) Length 306 a.a.

Antitoxin (Protein)


Gene name mosA Uniprot ID W8UPQ8
Locus tag NE847_RS25165 Protein ID WP_004151732.1
Coordinates 5069771..5070529 (-) Length 253 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE847_RS25140 (NE847_25140) 5064154..5065674 + 1521 WP_002885173.1 sugar ABC transporter ATP-binding protein -
NE847_RS25145 (NE847_25145) 5065671..5066669 + 999 WP_002885172.1 ribose ABC transporter permease -
NE847_RS25150 (NE847_25150) 5066700..5067641 + 942 WP_002885156.1 ABC transporter substrate-binding protein -
NE847_RS25155 (NE847_25155) 5067716..5068723 + 1008 WP_004151731.1 carbohydrate kinase family protein -
NE847_RS25160 (NE847_25160) 5068848..5069765 - 918 WP_002885155.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
NE847_RS25165 (NE847_25165) 5069771..5070529 - 759 WP_004151732.1 type IV toxin-antitoxin system AbiEi family antitoxin Antitoxin
NE847_RS25170 (NE847_25170) 5070615..5071343 - 729 WP_002885152.1 response regulator transcription factor -
NE847_RS25175 (NE847_25175) 5071616..5073763 + 2148 WP_077598858.1 formate dehydrogenase subunit alpha -
NE847_RS25180 (NE847_25180) 5073993..5074679 + 687 WP_004151733.1 tetratricopeptide repeat protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(14-278)

Antitoxin

Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system

(95-246)


Sequences

Toxin        


Download         Length: 306 a.a.        Molecular weight: 34687.15 Da        Isoelectric Point: 5.4707

>T248897 WP_002885155.1 NZ_CP099413:c5069765-5068848 [Klebsiella pneumoniae]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMSAVLQANRSDEMRVIVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELDRPIFNGFIVYLLSHNRPLAEVLNPRWKDIAEPFYREFSGMTFETIALEELTAVPNRMIAALKS
CFTQQDVDFLLSFKRGEPDWRLAPEMRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Download         Length: 918 bp

Antitoxin


Download         Length: 253 a.a.        Molecular weight: 28564.92 Da        Isoelectric Point: 10.0870

>AT248897 WP_004151732.1 NZ_CP099413:c5070529-5069771 [Klebsiella pneumoniae]
MATKLNWLLQNSAPGDVILQSWLSQHAISPSLSFKYAQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSVENKALLPKWFREFPGVEWIVISGKKLPVLDDRYRVTLDIKGKKLIGSAPELAAYELLS
AVPGTLSFNHAAELFQGLVNLNPRKVEYLLSVSQSVQAKRLYLFFASFYEHGWLKRIDSQKIDLGAGKRQIVENGKFNAQ
YQITVPERFQKE

Download         Length: 759 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GH11

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GQB5

References