Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4912664..4913180 Replicon chromosome
Accession NZ_CP099413
Organism Klebsiella pneumoniae strain 33367

Toxin (Protein)


Gene name relE Uniprot ID J2XDK6
Locus tag NE847_RS24360 Protein ID WP_002886902.1
Coordinates 4912664..4912948 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID R4Y888
Locus tag NE847_RS24365 Protein ID WP_002886901.1
Coordinates 4912938..4913180 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE847_RS24335 (NE847_24335) 4908148..4908411 - 264 WP_004152271.1 PTS sugar transporter subunit IIB -
NE847_RS24340 (NE847_24340) 4908541..4908714 + 174 WP_002886906.1 hypothetical protein -
NE847_RS24345 (NE847_24345) 4908717..4909460 + 744 WP_002886905.1 MurR/RpiR family transcriptional regulator -
NE847_RS24350 (NE847_24350) 4909817..4911955 + 2139 WP_002886904.1 anaerobic ribonucleoside-triphosphate reductase -
NE847_RS24355 (NE847_24355) 4912196..4912660 + 465 WP_002886903.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
NE847_RS24360 (NE847_24360) 4912664..4912948 - 285 WP_002886902.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NE847_RS24365 (NE847_24365) 4912938..4913180 - 243 WP_002886901.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NE847_RS24370 (NE847_24370) 4913258..4915168 - 1911 WP_004152270.1 PRD domain-containing protein -
NE847_RS24375 (NE847_24375) 4915191..4916345 - 1155 WP_002886900.1 lactonase family protein -
NE847_RS24380 (NE847_24380) 4916411..4917151 - 741 WP_002886899.1 KDGP aldolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-80)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11125.95 Da        Isoelectric Point: 10.3787

>T248896 WP_002886902.1 NZ_CP099413:c4912948-4912664 [Klebsiella pneumoniae]
MTYELEFDPRAWREWQKPGETVKKQFKNKLQQIVQNPRIESARLSDLPDCYKIKLKASGYRLVYQVRDSVVVVYVIAIGK
REKAAVYHQANKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9045.55 Da        Isoelectric Point: 6.3340

>AT248896 WP_002886901.1 NZ_CP099413:c4913180-4912938 [Klebsiella pneumoniae]
MATLNVRLDDKLKKEAYAVLEKLDMTPTEAVRLLFQYIAENGRMPVKSMTISDGEAALLRTVRERLENPRPGVKVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GMH2

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GLP0

References