Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2740353..2741941 Replicon chromosome
Accession NZ_CP099413
Organism Klebsiella pneumoniae strain 33367

Toxin (Protein)


Gene name hipA Uniprot ID A0A0H3GN97
Locus tag NE847_RS13575 Protein ID WP_004199851.1
Coordinates 2740353..2741675 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A0H3GXD8
Locus tag NE847_RS13580 Protein ID WP_002904790.1
Coordinates 2741675..2741941 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE847_RS13560 (NE847_13560) 2735418..2737919 + 2502 WP_004199853.1 fimbria/pilus outer membrane usher protein -
NE847_RS13565 (NE847_13565) 2737907..2738911 + 1005 WP_004199852.1 fimbrial protein -
NE847_RS13570 (NE847_13570) 2739044..2740336 + 1293 WP_002904794.1 glycoside hydrolase family 10 protein -
NE847_RS13575 (NE847_13575) 2740353..2741675 - 1323 WP_004199851.1 type II toxin-antitoxin system HipA family toxin Toxin
NE847_RS13580 (NE847_13580) 2741675..2741941 - 267 WP_002904790.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NE847_RS13585 (NE847_13585) 2742207..2742533 - 327 WP_002904788.1 hydroxyisourate hydrolase -
NE847_RS13590 (NE847_13590) 2742530..2743030 - 501 WP_002904787.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NE847_RS13595 (NE847_13595) 2743008..2744387 - 1380 WP_004199850.1 nucleobase:cation symporter-2 family protein -
NE847_RS13600 (NE847_13600) 2744733..2745887 + 1155 WP_002904783.1 FAD-dependent urate hydroxylase HpxO -
NE847_RS13605 (NE847_13605) 2745868..2746791 - 924 WP_004199849.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-402)

Antitoxin

Cro/C1-type helix-turn-helix domain

(16-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49128.44 Da        Isoelectric Point: 7.2487

>T248893 WP_004199851.1 NZ_CP099413:c2741675-2740353 [Klebsiella pneumoniae]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITSQDDFRISVAGAQEKTAL
LRMGEQWCIPQGATPTTHIIKLPIGEIKQPNATLDLRESVDNEYLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGLPSAMKYESDGGPGIAAIMTFLLGSSEALKDRYDFMKFMVFQWLTGATDGHAKNFSIYLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPLEQMLAILQEFAGHVP
QAIESARRTLPADFSSHVWQAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9906.27 Da        Isoelectric Point: 8.5912

>AT248893 WP_002904790.1 NZ_CP099413:c2741941-2741675 [Klebsiella pneumoniae]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKAAETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GN97

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GXD8

References