Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1741489..1742157 Replicon chromosome
Accession NC_014498
Organism Streptococcus pneumoniae 670-6B

Toxin (Protein)


Gene name hicA Uniprot ID B1I7Q0
Locus tag SP670_RS09285 Protein ID WP_001132285.1
Coordinates 1741978..1742157 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag SP670_RS09280 Protein ID WP_000961810.1
Coordinates 1741489..1741941 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP670_RS09260 1738338..1739372 - 1035 WP_000747916.1 ATP-binding protein -
SP670_RS09265 1739482..1739640 - 159 WP_000418164.1 hypothetical protein -
SP670_RS09270 1739621..1740709 - 1089 WP_000719720.1 M50 family metallopeptidase -
SP670_RS09275 1740728..1741198 - 471 WP_000257082.1 DUF3013 family protein -
SP670_RS09280 1741489..1741941 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
SP670_RS09285 1741978..1742157 - 180 WP_001132285.1 type II toxin-antitoxin system HicA family toxin Toxin
SP670_RS09290 1742294..1742473 - 180 WP_001048906.1 hypothetical protein -
SP670_RS09295 1742638..1742853 - 216 WP_075213559.1 hypothetical protein -
SP670_RS09300 1743151..1744422 + 1272 WP_001113213.1 replication-associated recombination protein A -
SP670_RS09310 1744969..1746288 - 1320 WP_000502563.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.01 Da        Isoelectric Point: 11.2964

>T24889 WP_001132285.1 NC_014498:c1742157-1741978 [Streptococcus pneumoniae 670-6B]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITILHGKLNKYTERGIRKQAGL

Download         Length: 180 bp

>T24889 NC_014498:c1742157-1741978 [Streptococcus pneumoniae 670-6B]
ATGCCTATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCCCA
TATTAAAATGGAAAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTAAGCTGAATAAGTACACTGAAAGAGGGATAA
GAAAGCAAGCTGGGTTGTAA

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT24889 WP_000961810.1 NC_014498:c1741941-1741489 [Streptococcus pneumoniae 670-6B]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp

>AT24889 NC_014498:c1741941-1741489 [Streptococcus pneumoniae 670-6B]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T9HEZ5

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References