Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-parE/ParE-RHH
Location 424738..425294 Replicon plasmid pRsp_Pop5_1
Accession NZ_CP099402
Organism Rhizobium sp. Pop5

Toxin (Protein)


Gene name parE Uniprot ID K0W5Z5
Locus tag NE852_RS30005 Protein ID WP_008532066.1
Coordinates 424738..425028 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID K0VVD3
Locus tag NE852_RS30010 Protein ID WP_008532065.1
Coordinates 425016..425294 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE852_RS29985 (NE852_29900) 420526..421482 - 957 WP_128623606.1 AraC family transcriptional regulator -
NE852_RS29990 (NE852_29905) 421628..422902 - 1275 WP_258157182.1 D-amino acid dehydrogenase -
NE852_RS29995 (NE852_29910) 422933..424063 - 1131 WP_008532068.1 alanine racemase -
NE852_RS30000 (NE852_29915) 424188..424652 + 465 WP_008532067.1 Lrp/AsnC family transcriptional regulator -
NE852_RS30005 (NE852_29920) 424738..425028 - 291 WP_008532066.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NE852_RS30010 (NE852_29925) 425016..425294 - 279 WP_008532065.1 CopG family ribbon-helix-helix protein Antitoxin
NE852_RS30015 (NE852_29930) 425421..426143 - 723 WP_258157183.1 LuxR family transcriptional regulator -
NE852_RS30020 (NE852_29935) 426346..426996 - 651 WP_037173719.1 acyl-homoserine-lactone synthase -
NE852_RS30025 (NE852_29940) 427178..427522 + 345 WP_008532056.1 helix-turn-helix domain-containing protein -
NE852_RS30030 (NE852_29945) 427699..428370 + 672 WP_037173716.1 hypothetical protein -
NE852_RS30035 (NE852_29950) 428389..429204 + 816 WP_245270643.1 hypothetical protein -
NE852_RS30040 (NE852_29955) 429422..429580 + 159 WP_164841444.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - htpB / htpB 1..951562 951562


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-94)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-42)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 10938.55 Da        Isoelectric Point: 7.2028

>T248881 WP_008532066.1 NZ_CP099402:c425028-424738 [Rhizobium sp. Pop5]
MPQVIFSPAAIRDLERLREFLRPKNPSAAKRAGETILKSVRALGMNPYMGRLVEDLPEQYREWLIDFGDSGDVVRYHIDG
DALTILAVRHQRDAGF

Download         Length: 291 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10732.94 Da        Isoelectric Point: 4.9253

>AT248881 WP_008532065.1 NZ_CP099402:c425294-425016 [Rhizobium sp. Pop5]
MASPTSLKLDDELKGRVQQLAEVRRRSSHWIMREAIAQYVEREEKREALRQETLNAWNEFQATGLHVTGDQVENWLSTWG
TDEELPAPECHK

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0W5Z5

Antitoxin

Source ID Structure
AlphaFold DB K0VVD3

References