Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 155317..155924 Replicon plasmid pRsp_Pop5_2
Accession NZ_CP099401
Organism Rhizobium sp. Pop5

Toxin (Protein)


Gene name hicA Uniprot ID K0VLN0
Locus tag NE852_RS26455 Protein ID WP_008530427.1
Coordinates 155670..155924 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NE852_RS26450 Protein ID WP_258156941.1
Coordinates 155317..155673 (-) Length 119 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NE852_RS26420 (NE852_26345) 150342..151343 + 1002 WP_008530417.1 NADP-dependent oxidoreductase -
NE852_RS26425 (NE852_26350) 151370..152221 + 852 WP_008530418.1 alpha/beta hydrolase -
NE852_RS26430 (NE852_26355) 152255..152674 + 420 Protein_140 aldo/keto reductase -
NE852_RS26435 (NE852_26360) 152743..153223 - 481 Protein_141 AraC family transcriptional regulator -
NE852_RS26440 (NE852_26365) 153611..154355 - 745 Protein_142 nucleotidyl transferase AbiEii/AbiGii toxin family protein -
NE852_RS26445 (NE852_26370) 154348..154941 - 594 WP_258156940.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
NE852_RS26450 (NE852_26375) 155317..155673 - 357 WP_258156941.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NE852_RS26455 (NE852_26380) 155670..155924 - 255 WP_008530427.1 type II toxin-antitoxin system HicA family toxin Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - gmd 1..503518 503518


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(23-81)

Antitoxin

Uncharacterised protein family HicB

(54-104)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 9294.62 Da        Isoelectric Point: 9.8124

>T248879 WP_008530427.1 NZ_CP099401:c155924-155670 [Rhizobium sp. Pop5]
MNSKQRKTLAAVFKDPVSGTIEWAAIENLLAAAGADVIEGNGSRVKFEKDGIIASFHRPHPDKEAKRYQVRDAREFLMQI
GVTP

Download         Length: 255 bp

Antitoxin


Download         Length: 119 a.a.        Molecular weight: 13274.91 Da        Isoelectric Point: 4.9838

>AT248879 WP_258156941.1 NZ_CP099401:c155673-155317 [Rhizobium sp. Pop5]
MNTMTYNGYHARIEFDAEDDVFFGKIAGISDIIGFHGDSVAELKKAFHEAVDDYLETCRRIGKEPQRPYSGKMMFRVAPE
VHRRAALAAELSGKSLNQWAEEVLEEAADHFAEARLPA

Download         Length: 357 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0VLN0

Antitoxin

Source ID Structure

References