Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1-StbC
Location 4253103..4253764 Replicon chromosome
Accession NZ_CP099397
Organism Pseudomonas hydrolytica strain DSWY01

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L1F06_RS19960 Protein ID WP_129481803.1
Coordinates 4253345..4253764 (+) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8I0VLZ4
Locus tag L1F06_RS19955 Protein ID WP_011921115.1
Coordinates 4253103..4253348 (+) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1F06_RS19930 (L1F06_019930) 4248645..4249394 + 750 WP_252576688.1 hypothetical protein -
L1F06_RS19935 (L1F06_019935) 4249400..4249759 + 360 WP_129481800.1 DUF2523 family protein -
L1F06_RS19940 (L1F06_019940) 4249762..4251087 + 1326 WP_129481801.1 zonular occludens toxin domain-containing protein -
L1F06_RS19945 (L1F06_019945) 4251000..4252058 + 1059 Protein_3934 hypothetical protein -
L1F06_RS19950 (L1F06_019950) 4252055..4253050 + 996 WP_129481802.1 tyrosine-type recombinase/integrase -
L1F06_RS19955 (L1F06_019955) 4253103..4253348 + 246 WP_011921115.1 Arc family DNA-binding protein Antitoxin
L1F06_RS19960 (L1F06_019960) 4253345..4253764 + 420 WP_129481803.1 type II toxin-antitoxin system VapC family toxin Toxin
L1F06_RS19970 (L1F06_019970) 4254159..4254386 + 228 WP_003244658.1 hypothetical protein -
L1F06_RS19975 (L1F06_019975) 4254383..4254736 - 354 WP_129481804.1 excalibur calcium-binding domain-containing protein -
L1F06_RS19980 (L1F06_019980) 4254875..4255039 + 165 WP_096825672.1 hypothetical protein -
L1F06_RS19985 (L1F06_019985) 4255066..4255512 + 447 WP_129481805.1 hypothetical protein -
L1F06_RS19990 (L1F06_019990) 4255521..4256099 - 579 WP_003244654.1 hypothetical protein -
L1F06_RS19995 (L1F06_019995) 4256201..4257112 - 912 WP_011921109.1 DMT family transporter -
L1F06_RS20000 (L1F06_020000) 4257449..4258156 - 708 WP_129481806.1 DNA/RNA nuclease SfsA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4235191..4257112 21921


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin

Arc-like DNA binding domain

(13-43)


Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15067.30 Da        Isoelectric Point: 4.2947

>T248876 WP_129481803.1 NZ_CP099397:4253345-4253764 [Pseudomonas hydrolytica]
MILLDTNVLSELMRAKPAPQVLEWVDAQPVGDLVITSITVAEILYGIARMPDGKRKQGLLDVASVMFDEDFAGNILPFDA
DAAVHYAEIAAETEAKGRVVDMADAQIAAIGRLHDAVIATRNIRHFETLGVALVDPWSN

Download         Length: 420 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8990.24 Da        Isoelectric Point: 10.7217

>AT248876 WP_011921115.1 NZ_CP099397:4253103-4253348 [Pseudomonas hydrolytica]
MAAITIRNLDDDLKAQLRIVAASHGRSMEEEVRFIIRQALSRQEKRGGLGSRIHSRFAAVGGADLELPERKTKARAASFD
E

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References