Detailed information of TA system TA248875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /Acetyltransf_4(toxin)
• Location: 3966829..3968240
• Replicon: chromosome
• Accession: NZ_CP099397
• Organism: Pseudomonas hydrolytica strain DSWY01

Toxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: L1F06_RS18620
• Protein ID: WP_129481677.1
• Coordinates: 3967671..3968240 (-)
• Length: 190 a.a.

Antitoxin (Protein)

• Gene name: -
• Uniprot ID: -
• Locus tag: L1F06_RS18615
• Protein ID: WP_003246035.1
• Coordinates: 3966829..3967668 (-)
• Length: 280 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1F06_RS18600 (L1F06_018600)	3963746..3964651	-	906	WP_129481674.1	GIDE domain-containing protein	-
L1F06_RS18605 (L1F06_018605)	3964653..3965225	-	573	WP_129481675.1	LemA family protein	-
L1F06_RS18610 (L1F06_018610)	3965416..3966753	+	1338	WP_129481676.1	imelysin family protein	-
L1F06_RS18615 (L1F06_018615)	3966829..3967668	-	840	WP_003246035.1	AraC family transcriptional regulator	Antitoxin
L1F06_RS18620 (L1F06_018620)	3967671..3968240	-	570	WP_129481677.1	GNAT family protein	Toxin
L1F06_RS18625 (L1F06_018625)	3968441..3971929	+	3489	WP_129481678.1	PAS domain-containing hybrid sensor histidine kinase/response regulator	-
L1F06_RS18630 (L1F06_018630)	3971972..3972790	-	819	WP_012019411.1	MerR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (14-146)

Antitoxin

• DNA binding HTH domain, AraC-type (197-274)

Sequences

Toxin

Protein

• Length: 190 a.a.
• Molecular weight: 21260.39 Da
• Isoelectric Point: 8.9246

>T248875 WP_129481677.1 NZ_CP099397:c3968240-3967671 [Pseudomonas hydrolytica]
MFKPQLVTLQRGALRLEPLADADIPALVALAEANRDELLYMSGTQPLDWYRSALAELREQRALPFAIRLGEQLVGTTRFG
DFMNSLPACEIGWTWLDRAQHGSGLNASIKYLMLKHAFDNWGMVRVQLKTAASNLRSQRAIEKLGAAREGLLRNHRRLAD
GRLDDTVLYSITDQEWPQVRAALEARFGG

Nucleotide

• Length: 570 bp

Antitoxin

Protein

• Length: 280 a.a.
• Molecular weight: 30956.10 Da
• Isoelectric Point: 7.7422

>AT248875 WP_003246035.1 NZ_CP099397:c3967668-3966829 [Pseudomonas hydrolytica]
MQPLTGSERARFSASDDLHGLELLSARFVEHRFAPHVHDGHVIAVLEAGAERYRYRGVDHLAGAGSIALLNPDEVHTGSK
GVEQGWQYRVFYPQPGTFEALLAELESPPAAPPMFHDSVHHDPLLASRLSALHRLLEDPHSEALQRQTLWREAMLELLQR
YARLPAPRGVGQEPRAVALAKELLASQLSEPPSLEELAAAVNLSPFHFARVFRRATGLPPHAWLRQRRLEQARTLLRSGC
SALSVAMQLGFADQSHLSRQFKQTYGVSPGEYRSAVARG

Nucleotide

• Length: 840 bp