Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/PRK09907(toxin)
Location 2502823..2503388 Replicon chromosome
Accession NZ_CP099396
Organism Lacticaseibacillus rhamnosus strain P118

Toxin (Protein)


Gene name mazF Uniprot ID C2JYM4
Locus tag NFI97_RS11565 Protein ID WP_005692155.1
Coordinates 2502823..2503170 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag NFI97_RS11570 Protein ID WP_020752297.1
Coordinates 2503170..2503388 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFI97_RS11545 2498318..2499559 - 1242 WP_005692160.1 acyltransferase -
NFI97_RS11550 2499556..2500257 - 702 WP_005692159.1 ATP-binding cassette domain-containing protein -
NFI97_RS11555 2500250..2501068 - 819 WP_014571588.1 ABC transporter permease subunit -
NFI97_RS11560 2501309..2501977 - 669 WP_005692157.1 phenylalanine--tRNA ligase beta subunit-related protein -
NFI97_RS11565 2502823..2503170 - 348 WP_005692155.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NFI97_RS11570 2503170..2503388 - 219 WP_020752297.1 hypothetical protein Antitoxin
NFI97_RS11575 2503482..2505317 - 1836 WP_015764721.1 ABC transporter ATP-binding protein -
NFI97_RS11580 2505304..2507094 - 1791 WP_015764722.1 ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(5-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 13150.01 Da        Isoelectric Point: 7.9817

>T248871 WP_005692155.1 NZ_CP099396:c2503170-2502823 [Lacticaseibacillus rhamnosus]
MTYKAKQGDVVWLDFDPSEGHEIRKRCPAVVLSSNAYNRATGFVIVAPITSTIRTLPGYVDIVSNKIRGQVVTSQVYSLD
VTEQGNRKIDFIERMNIEDFYTVAQFTKMNFDFKF

Download         Length: 348 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8117.33 Da        Isoelectric Point: 5.7995

>AT248871 WP_020752297.1 NZ_CP099396:c2503388-2503170 [Lacticaseibacillus rhamnosus]
MMDVKVVKRGNSLALSLPSSAGFKRGEAFLLISDEKGGYLLIPKVKNPYTKAKPLSFHQEEAWPDFDYEDIE

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z9DS75

Antitoxin

Source ID Structure

References