Detailed information of TA system TA024887

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1063602..1064848
• Replicon: chromosome
• Accession: NC_014498
• Organism: Streptococcus pneumoniae 670-6B

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: D6CHP4
• Locus tag: SP670_RS05645
• Protein ID: WP_000405382.1
• Coordinates: 1063602..1064372 (-)
• Length: 257 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: SP670_RS05650
• Protein ID: WP_000579618.1
• Coordinates: 1064372..1064848 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SP670_RS05625	1059230..1060153	+	924	WP_000417606.1	protein rep	-
SP670_RS05630	1060949..1061668	-	720	Protein_1071	type A chloramphenicol O-acetyltransferase	-
SP670_RS05635	1061839..1062087	-	249	WP_001814254.1	hypothetical protein	-
SP670_RS05640	1062335..1063141	-	807	WP_000214002.1	hypothetical protein	-
SP670_RS05645	1063602..1064372	-	771	WP_000405382.1	zeta toxin family protein	Toxin
SP670_RS05650	1064372..1064848	-	477	WP_000579618.1	helix-turn-helix domain-containing protein	Antitoxin
SP670_RS05655	1064919..1065191	-	273	WP_000495446.1	hypothetical protein	-
SP670_RS05660	1065229..1065612	-	384	WP_000159204.1	hypothetical protein	-
SP670_RS05665	1065609..1065842	-	234	WP_000152418.1	hypothetical protein	-
SP670_RS05670	1065893..1066978	-	1086	WP_000401900.1	toprim domain-containing protein	-
SP670_RS05675	1066988..1067629	-	642	WP_000933083.1	hypothetical protein	-
SP670_RS05690	1068804..1069688	+	885	WP_000583376.1	Rgg/GadR/MutR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	cat(pC194) / tet(M) / erm(B)	-	996270..1220179	223909

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-214)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 257 a.a.
• Molecular weight: 29495.56 Da
• Isoelectric Point: 7.9428

>T24887 WP_000405382.1 NC_014498:c1064372-1063602 [Streptococcus pneumoniae 670-6B]
MEIQDYTDSKFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQR
EYGKDSVEYTKDFAGKMVESLLTEFSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSGEDKISAAKVLQEYLFGKWSKVEEEML
KVGEERLEDLTNRNDC

Nucleotide

• Length: 771 bp

>T24887 NC_014498:c1064372-1063602 [Streptococcus pneumoniae 670-6B]
ATGGAAATCCAAGATTATACTGATAGTAAATTCAAACATGCTCTAGCACGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAGCAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGTGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCGA
GAATATGGCAAAGATAGTGTAGAATACACCAAAGATTTTGCAGGGAAAATGGTAGAGTCTTTACTAACCGAATTTAGTCA
TTTGGGATACAATCTTTTGATTGAAGGAACTTTACGAACAATTGATGTTCCAAAGAAAACAGCACAACTCTTGAAAAGTA
GGGGATATGAAGTACAATTAGCCTTGATTGCGACAAAGCCTAAGTTGTCCTATCTGAGCACCCTTATCCGATACGAAGAA
CTGTACGCTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
TACACGACAATTGGAAGAATTGGCTATCTTTGAAAGAATTCAAATTTATCAACGAGATAGAAGTTGTGTATATGATTCAG
GAGAAGATAAAATTTCAGCAGCAAAAGTGCTACAAGAATACCTCTTCGGAAAATGGAGCAAGGTAGAGGAAGAGATGTTG
AAGGTGGGAGAAGAAAGATTGGAAGATTTAACTAATCGAAATGATTGTTAG

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18254.69 Da
• Isoelectric Point: 4.4969

>AT24887 WP_000579618.1 NC_014498:c1064848-1064372 [Streptococcus pneumoniae 670-6B]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSHGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYTGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

>AT24887 NC_014498:c1064848-1064372 [Streptococcus pneumoniae 670-6B]
ATGATTGGAAAGAATATAAAATCCTTACGTAAAACACATGATTTAACCCAACCCGAATTTGCACGGATTGTAGGTATTTC
TCGAAATAGCTTAAGTCGTTATGAAAATGGAACGAGTTCAGTCTCTACGGAACTAATAGACATCATCTGCCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTAAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCATGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGACGATCTGTCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATACTGGCTATTTGGATGGAATTGAACGGATGTTAGAGATATCTGAAAAACGGATGGTAGCCTAA

Structures

Toxin

• AlphaFold DB: D6CHP4