Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 4455487..4456073 Replicon chromosome
Accession NZ_CP099394
Organism Paraburkholderia bryophila strain CA002

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NDK50_RS20210 Protein ID WP_111933386.1
Coordinates 4455487..4455669 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NDK50_RS20215 Protein ID WP_272625783.1
Coordinates 4455666..4456073 (+) Length 136 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NDK50_RS20185 (NDK50_20170) 4451203..4451628 - 426 WP_012434707.1 flagellar basal body rod protein FlgC -
NDK50_RS20190 (NDK50_20175) 4451724..4452218 - 495 WP_111933390.1 flagellar basal body rod protein FlgB -
NDK50_RS20195 (NDK50_20180) 4452437..4454062 + 1626 WP_272625777.1 flagellar basal body P-ring formation chaperone FlgA -
NDK50_RS20200 (NDK50_20185) 4454264..4454620 + 357 WP_272625779.1 flagellar biosynthesis anti-sigma factor FlgM -
NDK50_RS20205 (NDK50_20190) 4454715..4455161 + 447 WP_272625781.1 flagellar protein FlgN -
NDK50_RS20210 (NDK50_20195) 4455487..4455669 + 183 WP_111933386.1 type II toxin-antitoxin system HicA family toxin Toxin
NDK50_RS20215 (NDK50_20200) 4455666..4456073 + 408 WP_272625783.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NDK50_RS20220 (NDK50_20205) 4456192..4456926 - 735 WP_111933384.1 RNA polymerase sigma factor FliA -
NDK50_RS20225 (NDK50_20210) 4456955..4457824 - 870 WP_272625786.1 AAA family ATPase -
NDK50_RS20230 (NDK50_20215) 4457817..4459808 - 1992 WP_272625787.1 flagellar biosynthesis protein FlhF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(6-129)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6747.90 Da        Isoelectric Point: 11.7767

>T248868 WP_111933386.1 NZ_CP099394:4455487-4455669 [Paraburkholderia bryophila]
MNSAAVMKWIQANDWQLVRISGSHHHFRHPFRAGLVTIPHPKKDLPPGTLNSILKQAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 136 a.a.        Molecular weight: 14722.86 Da        Isoelectric Point: 4.7078

>AT248868 WP_272625783.1 NZ_CP099394:4455666-4456073 [Paraburkholderia bryophila]
MKNLIFPIALESGDDQHAYGVVVPDLPGCFAAGDTLEEAFANAKLAVESHLDTLLDEGLPVPQPLKLSEHRRNPDYAGFI
WGFVVTRNIPALKKAVRINISLPEVLVQDIDIYAQTRGLSRSSFLALAAEHEMAA

Download         Length: 408 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References