Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3802240..3802860 Replicon chromosome
Accession NZ_CP099390
Organism Citrobacter braakii strain RHB02-E3-C05

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ22_RS18720 Protein ID WP_002892050.1
Coordinates 3802642..3802860 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag NFJ22_RS18715 Protein ID WP_019076175.1
Coordinates 3802240..3802614 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ22_RS18705 (NFJ22_18700) 3797386..3798579 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ22_RS18710 (NFJ22_18705) 3798602..3801751 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ22_RS18715 (NFJ22_18710) 3802240..3802614 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
NFJ22_RS18720 (NFJ22_18715) 3802642..3802860 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ22_RS18725 (NFJ22_18720) 3803041..3803592 + 552 WP_016152072.1 maltose O-acetyltransferase -
NFJ22_RS18730 (NFJ22_18725) 3803709..3804179 + 471 WP_016152071.1 YlaC family protein -
NFJ22_RS18735 (NFJ22_18730) 3804258..3804398 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ22_RS18740 (NFJ22_18735) 3804400..3804660 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ22_RS18745 (NFJ22_18740) 3804848..3806401 + 1554 WP_047501906.1 EAL domain-containing protein -
NFJ22_RS18750 (NFJ22_18745) 3806453..3806806 - 354 WP_003831033.1 DUF1428 family protein -
NFJ22_RS18755 (NFJ22_18750) 3806871..3807500 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248861 WP_002892050.1 NZ_CP099390:3802642-3802860 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT248861 WP_019076175.1 NZ_CP099390:3802240-3802614 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References