Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 978438..978936 Replicon chromosome
Accession NC_014498
Organism Streptococcus pneumoniae 670-6B

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag SP670_RS05220 Protein ID WP_001809704.1
Coordinates 978682..978936 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag SP670_RS05215 Protein ID WP_000208080.1
Coordinates 978438..978680 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SP670_RS05195 974260..975435 + 1176 WP_000886145.1 A/G-specific adenine glycosylase -
SP670_RS05200 975490..976194 + 705 WP_000722076.1 response regulator transcription factor -
SP670_RS05205 976187..977536 + 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
SP670_RS05210 977538..978347 + 810 WP_001289493.1 MBL fold metallo-hydrolase -
SP670_RS05215 978438..978680 + 243 WP_000208080.1 hypothetical protein Antitoxin
SP670_RS05220 978682..978936 + 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SP670_RS05225 978983..979756 + 774 WP_000731131.1 ion transporter -
SP670_RS05230 980016..981002 - 987 WP_000204727.1 L-lactate dehydrogenase -
SP670_RS05235 981196..983664 + 2469 WP_001152990.1 DNA gyrase subunit A -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T24886 WP_001809704.1 NC_014498:978682-978936 [Streptococcus pneumoniae 670-6B]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T24886 NC_014498:978682-978936 [Streptococcus pneumoniae 670-6B]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTCGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT24886 WP_000208080.1 NC_014498:978438-978680 [Streptococcus pneumoniae 670-6B]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT24886 NC_014498:978438-978680 [Streptococcus pneumoniae 670-6B]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References