Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2508232..2508868 Replicon chromosome
Accession NZ_CP099390
Organism Citrobacter braakii strain RHB02-E3-C05

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NFJ22_RS12455 Protein ID WP_279264151.1
Coordinates 2508232..2508420 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ22_RS12460 Protein ID WP_131341011.1
Coordinates 2508452..2508868 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ22_RS12435 (NFJ22_12425) 2505010..2505240 - 231 WP_016156585.1 DUF2554 family protein -
NFJ22_RS12440 (NFJ22_12430) 2505430..2505555 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ22_RS12445 (NFJ22_12435) 2505555..2506565 - 1011 WP_279264150.1 cytochrome d ubiquinol oxidase subunit II -
NFJ22_RS12450 (NFJ22_12440) 2506565..2507968 - 1404 WP_047417372.1 cytochrome ubiquinol oxidase subunit I -
NFJ22_RS12455 (NFJ22_12445) 2508232..2508420 + 189 WP_279264151.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ22_RS12460 (NFJ22_12450) 2508452..2508868 + 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ22_RS12465 (NFJ22_12455) 2508961..2510370 + 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
NFJ22_RS12470 (NFJ22_12460) 2510700..2511845 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFJ22_RS12475 (NFJ22_12465) 2511862..2512878 + 1017 WP_016156582.1 ABC transporter ATP-binding protein -
NFJ22_RS12480 (NFJ22_12470) 2512879..2513823 + 945 WP_279264152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-55)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7132.18 Da        Isoelectric Point: 11.5775

>T248856 WP_279264151.1 NZ_CP099390:2508232-2508420 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLSLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT248856 WP_131341011.1 NZ_CP099390:2508452-2508868 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References