Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 865279..865933 Replicon chromosome
Accession NZ_CP099390
Organism Citrobacter braakii strain RHB02-E3-C05

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFJ22_RS04270 Protein ID WP_016154348.1
Coordinates 865526..865933 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFJ22_RS04265 Protein ID WP_016154349.1
Coordinates 865279..865545 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ22_RS04240 (NFJ22_04230) 860491..861924 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
NFJ22_RS04245 (NFJ22_04235) 862046..862774 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFJ22_RS04250 (NFJ22_04240) 862827..863138 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFJ22_RS04255 (NFJ22_04245) 863302..863961 + 660 WP_016154351.1 hemolysin III family protein -
NFJ22_RS04260 (NFJ22_04250) 864041..865021 - 981 WP_137352061.1 tRNA-modifying protein YgfZ -
NFJ22_RS04265 (NFJ22_04255) 865279..865545 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFJ22_RS04270 (NFJ22_04260) 865526..865933 + 408 WP_016154348.1 protein YgfX Toxin
NFJ22_RS04275 (NFJ22_04265) 866034..866555 - 522 WP_016154347.1 flavodoxin FldB -
NFJ22_RS04280 (NFJ22_04270) 866669..867565 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFJ22_RS04285 (NFJ22_04275) 867589..868302 + 714 WP_103766660.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ22_RS04290 (NFJ22_04280) 868308..870041 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248855 WP_016154348.1 NZ_CP099390:865526-865933 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248855 WP_016154349.1 NZ_CP099390:865279-865545 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References