248850

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3666101..3666721 Replicon chromosome
Accession NZ_CP099389
Organism Citrobacter braakii strain RHB02-E4-C01

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ24_RS17560 Protein ID WP_002892050.1
Coordinates 3666503..3666721 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NFJ24_RS17555 Protein ID WP_235116650.1
Coordinates 3666101..3666475 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ24_RS17545 (3661248) 3661248..3662441 + 1194 WP_053389373.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ24_RS17550 (3662464) 3662464..3665613 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ24_RS17555 (3666101) 3666101..3666475 + 375 WP_235116650.1 Hha toxicity modulator TomB Antitoxin
NFJ24_RS17560 (3666503) 3666503..3666721 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ24_RS17565 (3666902) 3666902..3667453 + 552 WP_016152072.1 maltose O-acetyltransferase -
NFJ24_RS17570 (3667570) 3667570..3668040 + 471 WP_016152071.1 YlaC family protein -
NFJ24_RS17575 (3668119) 3668119..3668259 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ24_RS17580 (3668261) 3668261..3668521 - 261 WP_235116651.1 type B 50S ribosomal protein L31 -
NFJ24_RS17585 (3668710) 3668710..3670263 + 1554 WP_047416867.1 EAL domain-containing protein -
NFJ24_RS17590 (3670315) 3670315..3670668 - 354 WP_003831033.1 DUF1428 family protein -
NFJ24_RS17595 (3670733) 3670733..3671362 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248850 WP_002892050.1 NZ_CP099389:3666503-3666721 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14439.24 Da        Isoelectric Point: 5.1292

>AT248850 WP_235116650.1 NZ_CP099389:3666101-3666475 [Citrobacter braakii]
MDEYSPKRYDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure

References