Detailed information of TA system TA024885

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mazEF/MazF-MazE
• Location: 37806..38383
• Replicon: plasmid pLM1-2bUG1
• Accession: NC_014495
• Organism: Listeria monocytogenes SLCC2755

Toxin (Protein)

• Gene name: mazF
• Uniprot ID: H1G8D6
• Locus tag: LMOSLCC2755_RS00185
• Protein ID: WP_003728465.1
• Coordinates: 37806..38147 (-)
• Length: 114 a.a.

Antitoxin (Protein)

• Gene name: mazE
• Uniprot ID: H1G8D5
• Locus tag: LMOSLCC2755_RS00190
• Protein ID: WP_003728464.1
• Coordinates: 38141..38383 (-)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LMOSLCC2755_RS00170	34285..34839	-	555	WP_003728468.1	recombinase family protein	-
LMOSLCC2755_RS00175	35119..35478	+	360	WP_003728467.1	Cd(II)-sensing metalloregulatory transcriptional repressor CadC	-
LMOSLCC2755_RS00180	35478..37613	+	2136	WP_003728466.1	cadmium-translocating P-type ATPase	-
LMOSLCC2755_RS00185	37806..38147	-	342	WP_003728465.1	type II toxin-antitoxin system PemK/MazF family toxin	Toxin
LMOSLCC2755_RS00190	38141..38383	-	243	WP_003728464.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
LMOSLCC2755_RS00195	38444..38695	-	252	WP_003728463.1	hypothetical protein	-
LMOSLCC2755_RS00200	38826..39152	+	327	WP_003728462.1	hypothetical protein	-
LMOSLCC2755_RS00205	39152..39814	+	663	WP_003731676.1	DUF2786 domain-containing protein	-
LMOSLCC2755_RS00210	39833..40210	+	378	WP_003769263.1	DUF3850 domain-containing protein	-
LMOSLCC2755_RS00215	40369..40857	+	489	WP_003728520.1	hypothetical protein	-
LMOSLCC2755_RS00220	40979..41227	+	249	WP_003728519.1	hypothetical protein	-
LMOSLCC2755_RS00225	41228..41653	+	426	WP_003728518.1	hypothetical protein	-
LMOSLCC2755_RS00230	41657..42379	+	723	WP_003728517.1	CRISPR-associated protein Cas5	-
LMOSLCC2755_RS00235	42395..43111	+	717	WP_003731678.1	AP2 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	-	1..57780	57780

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (5-84)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 114 a.a.
• Molecular weight: 16796.15 Da
• Isoelectric Point: 5.5500

>T24885 WP_003728465.1 NC_014495:c38147-37806 [Listeria monocytogenes]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF

Nucleotide

• Length: 342 bp

>T24885 NC_014495:c38147-37806 [Listeria monocytogenes]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTT

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 11939.32 Da
• Isoelectric Point: 5.5500

>AT24885 WP_003728464.1 NC_014495:c38383-38141 [Listeria monocytogenes]
FFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFFF
F

Nucleotide

• Length: 243 bp

>AT24885 NC_014495:c38383-38141 [Listeria monocytogenes]
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTT
TTT

Structures

Toxin

• AlphaFold DB: H1G8D6

Antitoxin

• AlphaFold DB: H1G8D5