Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2406650..2407286 Replicon chromosome
Accession NZ_CP099389
Organism Citrobacter braakii strain RHB02-E4-C01

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag NFJ24_RS11495 Protein ID WP_049259794.1
Coordinates 2406650..2406838 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ24_RS11500 Protein ID WP_131382557.1
Coordinates 2406870..2407286 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ24_RS11475 (2403427) 2403427..2403657 - 231 WP_016153158.1 DUF2554 family protein -
NFJ24_RS11480 (2403847) 2403847..2403972 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ24_RS11485 (2403972) 2403972..2404982 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFJ24_RS11490 (2404982) 2404982..2406385 - 1404 WP_047417372.1 cytochrome ubiquinol oxidase subunit I -
NFJ24_RS11495 (2406650) 2406650..2406838 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ24_RS11500 (2406870) 2406870..2407286 + 417 WP_131382557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ24_RS11505 (2407379) 2407379..2408788 + 1410 WP_235116830.1 PLP-dependent aminotransferase family protein -
NFJ24_RS11510 (2409118) 2409118..2410263 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFJ24_RS11515 (2410280) 2410280..2411296 + 1017 WP_153690354.1 ABC transporter ATP-binding protein -
NFJ24_RS11520 (2411297) 2411297..2412241 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248845 WP_049259794.1 NZ_CP099389:2406650-2406838 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT248845 WP_131382557.1 NZ_CP099389:2406870-2407286 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References