Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3623422..3624042 Replicon chromosome
Accession NZ_CP099388
Organism Citrobacter braakii strain RHB03-E1-C02

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ30_RS17345 Protein ID WP_002892050.1
Coordinates 3623824..3624042 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag NFJ30_RS17340 Protein ID WP_019076175.1
Coordinates 3623422..3623796 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ30_RS17330 (NFJ30_17320) 3618569..3619762 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ30_RS17335 (NFJ30_17325) 3619785..3622934 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ30_RS17340 (NFJ30_17330) 3623422..3623796 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
NFJ30_RS17345 (NFJ30_17335) 3623824..3624042 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ30_RS17350 (NFJ30_17340) 3624223..3624774 + 552 WP_046276082.1 maltose O-acetyltransferase -
NFJ30_RS17355 (NFJ30_17345) 3624891..3625361 + 471 WP_016152071.1 YlaC family protein -
NFJ30_RS17360 (NFJ30_17350) 3625439..3625579 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ30_RS17365 (NFJ30_17355) 3625581..3625841 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ30_RS17370 (NFJ30_17360) 3626030..3627583 + 1554 WP_053388979.1 EAL domain-containing protein -
NFJ30_RS17375 (NFJ30_17365) 3627635..3627988 - 354 WP_169330309.1 DUF1428 family protein -
NFJ30_RS17380 (NFJ30_17370) 3628053..3628682 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248839 WP_002892050.1 NZ_CP099388:3623824-3624042 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT248839 WP_019076175.1 NZ_CP099388:3623422-3623796 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References