Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2417908..2418544 Replicon chromosome
Accession NZ_CP099387
Organism Citrobacter braakii strain RHB08-E3-C01

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag NFJ49_RS11745 Protein ID WP_049259794.1
Coordinates 2417908..2418096 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ49_RS11750 Protein ID WP_131341011.1
Coordinates 2418128..2418544 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ49_RS11725 (2414686) 2414686..2414916 - 231 WP_016153158.1 DUF2554 family protein -
NFJ49_RS11730 (2415106) 2415106..2415231 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ49_RS11735 (2415231) 2415231..2416241 - 1011 WP_279273659.1 cytochrome d ubiquinol oxidase subunit II -
NFJ49_RS11740 (2416241) 2416241..2417644 - 1404 WP_047417372.1 cytochrome ubiquinol oxidase subunit I -
NFJ49_RS11745 (2417908) 2417908..2418096 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ49_RS11750 (2418128) 2418128..2418544 + 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ49_RS11755 (2418637) 2418637..2420046 + 1410 WP_185654626.1 PLP-dependent aminotransferase family protein -
NFJ49_RS11760 (2420376) 2420376..2421521 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFJ49_RS11765 (2421538) 2421538..2422554 + 1017 WP_279273660.1 ABC transporter ATP-binding protein -
NFJ49_RS11770 (2422555) 2422555..2423499 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248824 WP_049259794.1 NZ_CP099387:2417908-2418096 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT248824 WP_131341011.1 NZ_CP099387:2418128-2418544 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References