Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1185540..1186038 Replicon chromosome
Accession NC_014494
Organism Streptococcus pneumoniae AP200

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag SPAP_RS06170 Protein ID WP_001809704.1
Coordinates 1185540..1185794 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag SPAP_RS06175 Protein ID WP_000208080.1
Coordinates 1185796..1186038 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPAP_RS06155 1180801..1183269 - 2469 WP_001152992.1 DNA gyrase subunit A -
SPAP_RS06160 1183463..1184449 + 987 WP_000204727.1 L-lactate dehydrogenase -
SPAP_RS06165 1184798..1185493 - 696 WP_000731162.1 potassium channel family protein -
SPAP_RS06170 1185540..1185794 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
SPAP_RS06175 1185796..1186038 - 243 WP_000208080.1 hypothetical protein Antitoxin
SPAP_RS06180 1186129..1186938 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
SPAP_RS06185 1186940..1188289 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
SPAP_RS06190 1188282..1188986 - 705 WP_000722076.1 response regulator transcription factor -
SPAP_RS06195 1189041..1190216 - 1176 WP_000886153.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T24882 WP_001809704.1 NC_014494:c1185794-1185540 [Streptococcus pneumoniae AP200]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

>T24882 NC_014494:c1185794-1185540 [Streptococcus pneumoniae AP200]
TTGTATAAATTAGTTCCAACAAGACGTTTTATCAAGCAATTGAAAAAATTGGACCGTTATACGCAGAAGCTAATTACAAA
CTATTTACAAACCAATGTTTTGGAAGACCCAAGACGACACGGAAAGGCTTTGGTTGGTAATCGCGTTGGTCAATGGCGCT
ATAGAATTGGTAATTATCGAGTTATCGTACAAATTGTAGATGATGAATTAGTTGTTGCTACTCTAGAAGTTGGTCATCGG
AGAGATATTTATTGA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT24882 WP_000208080.1 NC_014494:c1186038-1185796 [Streptococcus pneumoniae AP200]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp

>AT24882 NC_014494:c1186038-1185796 [Streptococcus pneumoniae AP200]
ATGACTACTATTACATTAAAAGTTTCTGAAGCTGATAAAACATTTATGAAAGCAATGGCTAAGTTTGAAGGAGTTTCCCT
TTCGGAACTTATTCGCACCAAAACTCTTGAAGCCCTAGAAGATGAATACGATGCTCGTGTGGCAGATTTAGCCTATCAAG
AGTATTTAGAAGACTTGGAAAAAGGAGTTGAACCCATTACTTGGGAAGAAATGATGCATGATTTAGGCTTGAAGGATGAA
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References