Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3580085..3580705 Replicon chromosome
Accession NZ_CP099386
Organism Citrobacter braakii strain RHB09-E4-C01

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ61_RS17265 Protein ID WP_002892050.1
Coordinates 3580487..3580705 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag NFJ61_RS17260 Protein ID WP_019076175.1
Coordinates 3580085..3580459 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ61_RS17250 (3575232) 3575232..3576425 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ61_RS17255 (3576448) 3576448..3579597 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ61_RS17260 (3580085) 3580085..3580459 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
NFJ61_RS17265 (3580487) 3580487..3580705 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ61_RS17270 (3580886) 3580886..3581437 + 552 WP_016155874.1 maltose O-acetyltransferase -
NFJ61_RS17275 (3581554) 3581554..3582024 + 471 WP_016152071.1 YlaC family protein -
NFJ61_RS17280 (3582103) 3582103..3582243 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ61_RS17285 (3582245) 3582245..3582505 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ61_RS17290 (3582694) 3582694..3584247 + 1554 WP_047416867.1 EAL domain-containing protein -
NFJ61_RS17295 (3584299) 3584299..3584652 - 354 WP_003831033.1 DUF1428 family protein -
NFJ61_RS17300 (3584717) 3584717..3585346 - 630 WP_279272413.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248818 WP_002892050.1 NZ_CP099386:3580487-3580705 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT248818 WP_019076175.1 NZ_CP099386:3580085-3580459 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References