Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2348391..2349027 Replicon chromosome
Accession NZ_CP099386
Organism Citrobacter braakii strain RHB09-E4-C01

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag NFJ61_RS11305 Protein ID WP_049259794.1
Coordinates 2348391..2348579 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ61_RS11310 Protein ID WP_131382557.1
Coordinates 2348611..2349027 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ61_RS11285 (2345169) 2345169..2345399 - 231 WP_016153158.1 DUF2554 family protein -
NFJ61_RS11290 (2345589) 2345589..2345714 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ61_RS11295 (2345714) 2345714..2346724 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFJ61_RS11300 (2346724) 2346724..2348127 - 1404 WP_137367004.1 cytochrome ubiquinol oxidase subunit I -
NFJ61_RS11305 (2348391) 2348391..2348579 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ61_RS11310 (2348611) 2348611..2349027 + 417 WP_131382557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ61_RS11315 (2349120) 2349120..2350529 + 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
NFJ61_RS11320 (2350859) 2350859..2352004 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFJ61_RS11325 (2352021) 2352021..2353037 + 1017 WP_053389782.1 ABC transporter ATP-binding protein -
NFJ61_RS11330 (2353038) 2353038..2353982 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248813 WP_049259794.1 NZ_CP099386:2348391-2348579 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT248813 WP_131382557.1 NZ_CP099386:2348611-2349027 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References