Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4361732..4362258 Replicon chromosome
Accession NZ_CP099385
Organism Citrobacter braakii strain RHB09-SO-C07

Toxin (Protein)


Gene name relE Uniprot ID S1EXL1
Locus tag NFJ63_RS21010 Protein ID WP_000323025.1
Coordinates 4361971..4362258 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID S1F6D3
Locus tag NFJ63_RS21005 Protein ID WP_000534858.1
Coordinates 4361732..4361971 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ63_RS20985 (NFJ63_20980) 4357791..4359131 + 1341 WP_000589001.1 ISNCY family transposase -
NFJ63_RS20990 (NFJ63_20985) 4359774..4360346 + 573 WP_001515348.1 cytochrome b/b6 domain-containing protein -
NFJ63_RS20995 (NFJ63_20990) 4360546..4361469 + 924 WP_000167917.1 cation diffusion facilitator family transporter -
NFJ63_RS21000 (NFJ63_20995) 4361603..4361707 - 105 Protein_4120 protein YdfV -
NFJ63_RS21005 (NFJ63_21000) 4361732..4361971 + 240 WP_000534858.1 type II toxin-antitoxin system antitoxin RelB Antitoxin
NFJ63_RS21010 (NFJ63_21005) 4361971..4362258 + 288 WP_000323025.1 type II toxin-antitoxin system mRNA interferase RelE Toxin
NFJ63_RS21015 (NFJ63_21010) 4362684..4362890 + 207 WP_001585285.1 AlpA family transcriptional regulator -
NFJ63_RS21020 (NFJ63_21015) 4362988..4363587 + 600 WP_089513907.1 hypothetical protein -
NFJ63_RS21025 (NFJ63_21020) 4363779..4364348 + 570 WP_042017752.1 inovirus-type Gp2 protein -
NFJ63_RS21030 (NFJ63_21025) 4364739..4366520 - 1782 WP_001585282.1 ATP-dependent helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - hcp/tssD 4345883..4374283 28400


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-86)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-79)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11225.22 Da        Isoelectric Point: 10.1967

>T248808 WP_000323025.1 NZ_CP099385:4361971-4362258 [Citrobacter braakii]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL

Download         Length: 288 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9071.48 Da        Isoelectric Point: 4.5230

>AT248808 WP_000534858.1 NZ_CP099385:4361732-4361971 [Citrobacter braakii]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4V7K
PDB 4V7J
PDB 4FXI
PDB 4FXE
PDB 2KC8
PDB 4FXH
PDB 2KC9

Antitoxin

Source ID Structure
PDB 4FXE
PDB 2KC8
PDB 2K29
AlphaFold DB A0A4V1CTS8

References