Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3720424..3721044 Replicon chromosome
Accession NZ_CP099385
Organism Citrobacter braakii strain RHB09-SO-C07

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ63_RS17965 Protein ID WP_002892050.1
Coordinates 3720826..3721044 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag NFJ63_RS17960 Protein ID WP_019076175.1
Coordinates 3720424..3720798 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ63_RS17950 (NFJ63_17945) 3715570..3716763 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ63_RS17955 (NFJ63_17950) 3716786..3719935 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ63_RS17960 (NFJ63_17955) 3720424..3720798 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
NFJ63_RS17965 (NFJ63_17960) 3720826..3721044 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ63_RS17970 (NFJ63_17965) 3721225..3721776 + 552 WP_016152072.1 maltose O-acetyltransferase -
NFJ63_RS17975 (NFJ63_17970) 3721893..3722363 + 471 WP_016152071.1 YlaC family protein -
NFJ63_RS17980 (NFJ63_17975) 3722442..3722582 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ63_RS17985 (NFJ63_17980) 3722584..3722844 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ63_RS17990 (NFJ63_17985) 3723033..3724586 + 1554 WP_153690662.1 EAL domain-containing protein -
NFJ63_RS17995 (NFJ63_17990) 3724638..3724991 - 354 WP_003831033.1 DUF1428 family protein -
NFJ63_RS18000 (NFJ63_17995) 3725056..3725685 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248805 WP_002892050.1 NZ_CP099385:3720826-3721044 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT248805 WP_019076175.1 NZ_CP099385:3720424-3720798 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References