Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | spoIISABC/SpoIISA-SpoIISB |
| Location | 1307000..1307916 | Replicon | chromosome |
| Accession | NC_014479 | ||
| Organism | Bacillus subtilis subsp. spizizenii str. W23 | ||
Toxin (Protein)
| Gene name | spoIISA | Uniprot ID | - |
| Locus tag | BSUW23_RS06840 | Protein ID | WP_003218453.1 |
| Coordinates | 1307170..1307916 (-) | Length | 249 a.a. |
Antitoxin (Protein)
| Gene name | spoIISB | Uniprot ID | - |
| Locus tag | BSUW23_RS06835 | Protein ID | WP_003218451.1 |
| Coordinates | 1307000..1307170 (-) | Length | 57 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BSUW23_RS06805 | 1303864..1304190 | + | 327 | WP_003218439.1 | XkdW family protein | - |
| BSUW23_RS06810 | 1304187..1304351 | + | 165 | WP_003218441.1 | XkdX family protein | - |
| BSUW23_RS06815 | 1304396..1305235 | + | 840 | WP_003218443.1 | hypothetical protein | - |
| BSUW23_RS06820 | 1305288..1305557 | + | 270 | WP_003218444.1 | hemolysin XhlA family protein | - |
| BSUW23_RS06825 | 1305570..1305833 | + | 264 | WP_003218447.1 | phage holin | - |
| BSUW23_RS06830 | 1305846..1306739 | + | 894 | WP_003218449.1 | N-acetylmuramoyl-L-alanine amidase | - |
| BSUW23_RS21195 | 1306777..1306914 | - | 138 | WP_136654612.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISC | - |
| BSUW23_RS06835 | 1307000..1307170 | - | 171 | WP_003218451.1 | three component toxin-antitoxin-antitoxin system antitoxin SpoIISB | Antitoxin |
| BSUW23_RS06840 | 1307170..1307916 | - | 747 | WP_003218453.1 | toxin-antitoxin-antitoxin system toxin SpoIISA | Toxin |
| BSUW23_RS06845 | 1308026..1309027 | - | 1002 | WP_003218455.1 | inorganic phosphate transporter | - |
| BSUW23_RS06850 | 1309040..1309657 | - | 618 | WP_003218470.1 | DUF47 domain-containing protein | - |
| BSUW23_RS06855 | 1309934..1311250 | - | 1317 | WP_003218471.1 | serine/threonine exchanger | - |
| BSUW23_RS06860 | 1311633..1312583 | + | 951 | WP_003218472.1 | ring-cleaving dioxygenase | - |
| BSUW23_RS21200 | 1312684..1312830 | + | 147 | WP_003218473.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 249 a.a. Molecular weight: 29067.56 Da Isoelectric Point: 4.6878
>T24880 WP_003218453.1 NC_014479:c1307916-1307170 [Bacillus subtilis subsp. spizizenii str. W23]
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYDSSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKNRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFIIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
MLLFFQIMVWCIMAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYDSSSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIEAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKNRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFIIETQSYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG
Download Length: 747 bp
>T24880 NC_014479:c1307916-1307170 [Bacillus subtilis subsp. spizizenii str. W23]
ATGCTTTTATTCTTTCAGATCATGGTCTGGTGCATCATGGCCGGATTGGGCTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCTATCCGGAAAACATGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGATTCCTCTTCCCTGTTTACTCACTGGGAACGGTATCTCATTGTCGCCGTCAGTTTTGCTTTAATTGACGCTTTC
ATCTTCTTAAGCGCATACGTCAAAAAACTGGCCGGCAGCGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCACGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCCGATAAAATGAACTTAACGGCCTCCCTT
TGTCACTATTCGACACAGGCTGATAAAAACCGGTTAACAGAGCATATGGACGATCCGGCAGACGTGCAAACTCGTCTTGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTATCATCGAGACACAGAGTTACGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTTTTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA
ATGCTTTTATTCTTTCAGATCATGGTCTGGTGCATCATGGCCGGATTGGGCTTATACGTGTATGCCACGTGGCGTTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCTATCCGGAAAACATGGTATTTGCTGTTTGTTCTGGGCGCTATGGTATACTGGA
CATATGATTCCTCTTCCCTGTTTACTCACTGGGAACGGTATCTCATTGTCGCCGTCAGTTTTGCTTTAATTGACGCTTTC
ATCTTCTTAAGCGCATACGTCAAAAAACTGGCCGGCAGCGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCAATCGGCTGAAAACATACCAATACCTATTGAAAAACGAACCGATCCACGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGTATTGATAAACTGCTGAAAACCTATGCCGATAAAATGAACTTAACGGCCTCCCTT
TGTCACTATTCGACACAGGCTGATAAAAACCGGTTAACAGAGCATATGGACGATCCGGCAGACGTGCAAACTCGTCTTGA
TCGAAAGGATGTTTATTACGACCAATACGGAAAAGTGGTTCTCATCCCTTTTATCATCGAGACACAGAGTTACGTCATCA
AGCTGACGTCTGACAGCATTGTCACGGAATTTGATTATTTGCTTTTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA
Antitoxin
Download Length: 57 a.a. Molecular weight: 6545.55 Da Isoelectric Point: 10.8401
>AT24880 WP_003218451.1 NC_014479:c1307170-1307000 [Bacillus subtilis subsp. spizizenii str. W23]
MERAFQNGCEPRAAKSFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
MERAFQNGCEPRAAKSFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA
Download Length: 171 bp
>AT24880 NC_014479:c1307170-1307000 [Bacillus subtilis subsp. spizizenii str. W23]
ATGGAACGCGCATTTCAAAACGGATGCGAGCCCCGCGCGGCGAAGTCGTTTAAAATCCTGAAGAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGCCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA
ATGGAACGCGCATTTCAAAACGGATGCGAGCCCCGCGCGGCGAAGTCGTTTAAAATCCTGAAGAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGCCCGCATACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGACGAGTATAAACGAA
AAAAAGCATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|