Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 845927..846581 Replicon chromosome
Accession NZ_CP099385
Organism Citrobacter braakii strain RHB09-SO-C07

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFJ63_RS04115 Protein ID WP_016154348.1
Coordinates 846174..846581 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFJ63_RS04110 Protein ID WP_016154349.1
Coordinates 845927..846193 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ63_RS04085 (NFJ63_04085) 841139..842572 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
NFJ63_RS04090 (NFJ63_04090) 842694..843422 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFJ63_RS04095 (NFJ63_04095) 843475..843786 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFJ63_RS04100 (NFJ63_04100) 843950..844609 + 660 WP_153690042.1 hemolysin III family protein -
NFJ63_RS04105 (NFJ63_04105) 844689..845669 - 981 WP_153690043.1 tRNA-modifying protein YgfZ -
NFJ63_RS04110 (NFJ63_04110) 845927..846193 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFJ63_RS04115 (NFJ63_04115) 846174..846581 + 408 WP_016154348.1 protein YgfX Toxin
NFJ63_RS04120 (NFJ63_04120) 846682..847203 - 522 WP_016154347.1 flavodoxin FldB -
NFJ63_RS04125 (NFJ63_04125) 847317..848213 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFJ63_RS04130 (NFJ63_04130) 848237..848950 + 714 WP_153690044.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ63_RS04135 (NFJ63_04135) 848956..850689 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248799 WP_016154348.1 NZ_CP099385:846174-846581 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248799 WP_016154349.1 NZ_CP099385:845927-846193 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References