Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3581066..3581686 Replicon chromosome
Accession NZ_CP099384
Organism Citrobacter braakii strain RHB13-SO-C07

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ78_RS17120 Protein ID WP_002892050.1
Coordinates 3581468..3581686 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFJ78_RS17115 Protein ID WP_003021733.1
Coordinates 3581066..3581440 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ78_RS17105 (3576213) 3576213..3577406 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ78_RS17110 (3577429) 3577429..3580578 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ78_RS17115 (3581066) 3581066..3581440 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFJ78_RS17120 (3581468) 3581468..3581686 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ78_RS17125 (3581867) 3581867..3582418 + 552 WP_103283555.1 maltose O-acetyltransferase -
NFJ78_RS17130 (3582535) 3582535..3583005 + 471 WP_016152071.1 YlaC family protein -
NFJ78_RS17135 (3583084) 3583084..3583224 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ78_RS17140 (3583226) 3583226..3583486 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ78_RS17145 (3583675) 3583675..3585228 + 1554 WP_016155873.1 EAL domain-containing protein -
NFJ78_RS17150 (3585280) 3585280..3585633 - 354 WP_003831033.1 DUF1428 family protein -
NFJ78_RS17155 (3585698) 3585698..3586327 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248793 WP_002892050.1 NZ_CP099384:3581468-3581686 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248793 WP_003021733.1 NZ_CP099384:3581066-3581440 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References