Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | mazEF/MazF(toxin) |
| Location | 506485..507121 | Replicon | chromosome |
| Accession | NC_014479 | ||
| Organism | Bacillus subtilis subsp. spizizenii str. W23 | ||
Toxin (Protein)
| Gene name | mazF | Uniprot ID | G4NU33 |
| Locus tag | BSUW23_RS02585 | Protein ID | WP_003156187.1 |
| Coordinates | 506771..507121 (+) | Length | 117 a.a. |
Antitoxin (Protein)
| Gene name | mazE | Uniprot ID | G4NU32 |
| Locus tag | BSUW23_RS02580 | Protein ID | WP_003225183.1 |
| Coordinates | 506485..506766 (+) | Length | 94 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| BSUW23_RS02560 | 502845..503444 | - | 600 | WP_003225175.1 | rhomboid family intramembrane serine protease | - |
| BSUW23_RS02565 | 503539..503904 | + | 366 | WP_003225177.1 | holo-ACP synthase | - |
| BSUW23_RS02570 | 504069..505085 | + | 1017 | WP_072181690.1 | outer membrane lipoprotein carrier protein LolA | - |
| BSUW23_RS02575 | 505200..506369 | + | 1170 | WP_003225181.1 | alanine racemase | - |
| BSUW23_RS02580 | 506485..506766 | + | 282 | WP_003225183.1 | type II toxin-antitoxin system antitoxin EndoAI | Antitoxin |
| BSUW23_RS02585 | 506771..507121 | + | 351 | WP_003156187.1 | type II toxin-antitoxin system endoribonuclease NdoA | Toxin |
| BSUW23_RS02590 | 507239..508063 | + | 825 | WP_013307919.1 | RsbT co-antagonist protein RsbRA | - |
| BSUW23_RS02595 | 508068..508433 | + | 366 | WP_003225190.1 | RsbT antagonist protein RsbS | - |
| BSUW23_RS02600 | 508437..508838 | + | 402 | WP_003225192.1 | serine/threonine-protein kinase RsbT | - |
| BSUW23_RS02605 | 508850..509857 | + | 1008 | WP_003225194.1 | phosphoserine phosphatase RsbU | - |
| BSUW23_RS02610 | 509919..510248 | + | 330 | WP_003225196.1 | anti-sigma factor antagonist RsbV | - |
| BSUW23_RS02615 | 510245..510727 | + | 483 | WP_003225198.1 | anti-sigma B factor RsbW | - |
| BSUW23_RS02620 | 510693..511481 | + | 789 | WP_003225200.1 | RNA polymerase sigma factor SigB | - |
| BSUW23_RS02625 | 511481..512080 | + | 600 | WP_003225202.1 | phosphoserine phosphatase RsbX | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 117 a.a. Molecular weight: 12977.98 Da Isoelectric Point: 4.8781
>T24879 WP_003156187.1 NC_014479:506771-507121 [Bacillus subtilis subsp. spizizenii str. W23]
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
MIVKRGDVYFADLSPVVGSEQGGVRPVLVIQNDIGNRFSPTAIVAAITAQIQKAKLPTHVEIDAKRYGFERDSVILLEQI
RTIDKQRLTDKITHLDDEMMDKVDEALQISLALIDF
Download Length: 351 bp
>T24879 NC_014479:506771-507121 [Bacillus subtilis subsp. spizizenii str. W23]
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
TTGATTGTGAAACGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGGGTGCGCCCGGT
TTTAGTGATCCAAAATGACATCGGAAATCGCTTCAGCCCAACTGCTATTGTTGCAGCCATAACAGCACAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATCGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAGATTACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
ACAAATCAGTTTGGCACTCATTGATTTTTAG
Antitoxin
Download Length: 94 a.a. Molecular weight: 10546.92 Da Isoelectric Point: 6.4708
>AT24879 WP_003225183.1 NC_014479:506485-506766 [Bacillus subtilis subsp. spizizenii str. W23]
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
MSESSARTEMKISLPENLVAELDGVAMREKRSRNELISQAVRAYVSERTTRHNRDLMRRGYMEMAKINLNISSEAHFAEC
EAETTVERLVSGG
Download Length: 282 bp
>AT24879 NC_014479:506485-506766 [Bacillus subtilis subsp. spizizenii str. W23]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCCGAAAACCTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGAACAACTCGTCACAACC
GTGATTTGATGAGACGCGGCTATATGGAAATGGCGAAAATCAACCTGAATATTTCTTCTGAGGCTCACTTTGCGGAGTGC
GAGGCTGAAACGACAGTTGAGCGCTTAGTCAGCGGAGGATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|