Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2342925..2343561 Replicon chromosome
Accession NZ_CP099384
Organism Citrobacter braakii strain RHB13-SO-C07

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NFJ78_RS11170 Protein ID WP_222186171.1
Coordinates 2342925..2343113 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ78_RS11175 Protein ID WP_131382557.1
Coordinates 2343145..2343561 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ78_RS11150 (2339703) 2339703..2339933 - 231 WP_016153158.1 DUF2554 family protein -
NFJ78_RS11155 (2340123) 2340123..2340248 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ78_RS11160 (2340248) 2340248..2341258 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFJ78_RS11165 (2341258) 2341258..2342661 - 1404 WP_137367004.1 cytochrome ubiquinol oxidase subunit I -
NFJ78_RS11170 (2342925) 2342925..2343113 + 189 WP_222186171.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ78_RS11175 (2343145) 2343145..2343561 + 417 WP_131382557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ78_RS11180 (2343654) 2343654..2345063 + 1410 WP_279262912.1 PLP-dependent aminotransferase family protein -
NFJ78_RS11185 (2345393) 2345393..2346538 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFJ78_RS11190 (2346555) 2346555..2347571 + 1017 WP_016153153.1 ABC transporter ATP-binding protein -
NFJ78_RS11195 (2347572) 2347572..2348516 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 6972.99 Da        Isoelectric Point: 11.5775

>T248787 WP_222186171.1 NZ_CP099384:2342925-2343113 [Citrobacter braakii]
VKQSEFRRGLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT248787 WP_131382557.1 NZ_CP099384:2343145-2343561 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References