Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 872802..873456 Replicon chromosome
Accession NZ_CP099384
Organism Citrobacter braakii strain RHB13-SO-C07

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFJ78_RS04255 Protein ID WP_016154348.1
Coordinates 873049..873456 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFJ78_RS04250 Protein ID WP_016154349.1
Coordinates 872802..873068 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ78_RS04225 (868015) 868015..869448 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
NFJ78_RS04230 (869569) 869569..870297 - 729 WP_103284472.1 MurR/RpiR family transcriptional regulator -
NFJ78_RS04235 (870350) 870350..870661 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFJ78_RS04240 (870825) 870825..871484 + 660 WP_016154351.1 hemolysin III family protein -
NFJ78_RS04245 (871564) 871564..872544 - 981 WP_016154350.1 tRNA-modifying protein YgfZ -
NFJ78_RS04250 (872802) 872802..873068 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFJ78_RS04255 (873049) 873049..873456 + 408 WP_016154348.1 protein YgfX Toxin
NFJ78_RS04260 (873557) 873557..874078 - 522 WP_016154347.1 flavodoxin FldB -
NFJ78_RS04265 (874192) 874192..875088 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFJ78_RS04270 (875112) 875112..875825 + 714 WP_075847456.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ78_RS04275 (875831) 875831..877564 + 1734 WP_049269301.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248786 WP_016154348.1 NZ_CP099384:873049-873456 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248786 WP_016154349.1 NZ_CP099384:872802-873068 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References