Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3803046..3803666 Replicon chromosome
Accession NZ_CP099382
Organism Citrobacter braakii strain RHB14-SO-C08

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ83_RS18420 Protein ID WP_002892050.1
Coordinates 3803448..3803666 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFJ83_RS18415 Protein ID WP_003021733.1
Coordinates 3803046..3803420 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ83_RS18405 (3798193) 3798193..3799386 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ83_RS18410 (3799409) 3799409..3802558 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ83_RS18415 (3803046) 3803046..3803420 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFJ83_RS18420 (3803448) 3803448..3803666 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ83_RS18425 (3803847) 3803847..3804398 + 552 WP_103283555.1 maltose O-acetyltransferase -
NFJ83_RS18430 (3804515) 3804515..3804985 + 471 WP_016152071.1 YlaC family protein -
NFJ83_RS18435 (3805063) 3805063..3805203 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ83_RS18440 (3805205) 3805205..3805465 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ83_RS18445 (3805654) 3805654..3807207 + 1554 WP_047416867.1 EAL domain-containing protein -
NFJ83_RS18450 (3807259) 3807259..3807612 - 354 WP_003831033.1 DUF1428 family protein -
NFJ83_RS18455 (3807677) 3807677..3808306 - 630 WP_103283554.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248781 WP_002892050.1 NZ_CP099382:3803448-3803666 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248781 WP_003021733.1 NZ_CP099382:3803046-3803420 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References