Detailed information of TA system TA024878

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN-MazE
• Location: 2830106..2830739
• Replicon: chromosome
• Accession: NC_014414
• Organism: Parvularcula bermudensis HTCC2503

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: PB2503_RS13200
• Protein ID: WP_013301769.1
• Coordinates: 2830326..2830739 (+)
• Length: 138 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: E0THY3
• Locus tag: PB2503_RS13195
• Protein ID: WP_013301768.1
• Coordinates: 2830106..2830336 (+)
• Length: 77 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PB2503_RS13185	2826367..2826798	+	432	WP_013301764.1	transcriptional repressor	-
PB2503_RS14895	2826936..2827112	+	177	WP_202944385.1	hypothetical protein	-
PB2503_RS13190	2827741..2829192	-	1452	WP_158305857.1	D-alanyl-D-alanine carboxypeptidase/D-alanyl-D-alanine-endopeptidase	-
PB2503_RS13195	2830106..2830336	+	231	WP_013301768.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
PB2503_RS13200	2830326..2830739	+	414	WP_013301769.1	PIN domain-containing protein	Toxin
PB2503_RS13205	2830785..2831168	-	384	WP_013301770.1	hypothetical protein	-
PB2503_RS13210	2831168..2831887	-	720	WP_013301771.1	PepSY domain-containing protein	-
PB2503_RS13215	2831891..2832313	-	423	WP_013301772.1	copper-binding protein	-
PB2503_RS13220	2832332..2835523	-	3192	WP_049782017.1	efflux RND transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (7-120)

Antitoxin

• SpoVT-AbrB domain (5-33)

Sequences

Toxin

Protein

• Length: 138 a.a.
• Molecular weight: 15812.03 Da
• Isoelectric Point: 6.2383

>T24878 WP_013301769.1 NC_014414:2830326-2830739 [Parvularcula bermudensis HTCC2503]
MSGEPRVFIDTNVLLYLLSADTRKADRAEEILRSDRLDRRVSTQVIAEFAVNLHRKAGLDWPTIRVHIETLRLVCAVETV
LSRDQDTAMELAERYRFSWWDAQILAVAQRCGAKTLYSEDLQHGQDVRGLRIENPFL

Nucleotide

• Length: 414 bp

>T24878 NC_014414:2830326-2830739 [Parvularcula bermudensis HTCC2503]
ATGAGCGGTGAGCCGCGGGTTTTCATCGACACGAACGTCCTTCTCTACCTTCTATCTGCCGACACCCGGAAAGCGGACCG
AGCCGAAGAGATCCTGCGATCGGATCGGCTCGACCGGCGGGTCTCGACACAGGTAATCGCCGAATTCGCTGTCAATCTAC
ACCGCAAGGCGGGTCTGGACTGGCCGACGATCCGCGTTCACATCGAGACGCTCCGCCTCGTCTGCGCCGTCGAAACCGTT
CTGAGTAGAGACCAGGACACCGCGATGGAGCTCGCCGAACGATATCGCTTCAGTTGGTGGGATGCGCAGATCCTTGCCGT
CGCGCAGCGCTGTGGCGCGAAAACCCTCTATTCGGAGGATCTCCAGCACGGACAGGACGTGAGAGGTCTCAGGATCGAGA
ATCCCTTCCTGTAG

Antitoxin

Protein

• Length: 77 a.a.
• Molecular weight: 8584.76 Da
• Isoelectric Point: 5.6994

>AT24878 WP_013301768.1 NC_014414:2830106-2830336 [Parvularcula bermudensis HTCC2503]
MQVSKWGNSLAVRLPADLVDKLGLKEGDDIELLSLGKHQFGVERALTLDERFALLRQARGRLSETVEIDRDATHER

Nucleotide

• Length: 231 bp

>AT24878 NC_014414:2830106-2830336 [Parvularcula bermudensis HTCC2503]
ATGCAAGTGTCGAAATGGGGAAACAGTTTGGCGGTACGCTTGCCCGCCGATCTCGTCGATAAACTCGGATTGAAAGAAGG
CGACGACATTGAGCTTCTTTCTCTCGGGAAGCATCAGTTCGGCGTCGAGCGAGCCCTGACCCTCGATGAGCGCTTCGCGC
TCCTCCGCCAGGCACGGGGCCGGTTAAGCGAGACCGTCGAGATAGATCGCGACGCCACCCATGAGCGGTGA

Structures

Antitoxin

• AlphaFold DB: E0THY3