Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3723761..3724381 Replicon chromosome
Accession NZ_CP099381
Organism Citrobacter braakii strain RHB16-E2-C02

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ84_RS18100 Protein ID WP_002892050.1
Coordinates 3724163..3724381 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A7L6U5G9
Locus tag NFJ84_RS18095 Protein ID WP_019076175.1
Coordinates 3723761..3724135 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ84_RS18085 (NFJ84_18070) 3718907..3720100 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ84_RS18090 (NFJ84_18075) 3720123..3723272 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ84_RS18095 (NFJ84_18080) 3723761..3724135 + 375 WP_019076175.1 Hha toxicity modulator TomB Antitoxin
NFJ84_RS18100 (NFJ84_18085) 3724163..3724381 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ84_RS18105 (NFJ84_18090) 3724562..3725113 + 552 WP_016152072.1 maltose O-acetyltransferase -
NFJ84_RS18110 (NFJ84_18095) 3725230..3725700 + 471 WP_016152071.1 YlaC family protein -
NFJ84_RS18115 (NFJ84_18100) 3725779..3725919 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ84_RS18120 (NFJ84_18105) 3725921..3726181 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ84_RS18125 (NFJ84_18110) 3726370..3727923 + 1554 WP_279265195.1 EAL domain-containing protein -
NFJ84_RS18130 (NFJ84_18115) 3727975..3728328 - 354 WP_080858962.1 DUF1428 family protein -
NFJ84_RS18135 (NFJ84_18120) 3728393..3729022 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248770 WP_002892050.1 NZ_CP099381:3724163-3724381 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14413.20 Da        Isoelectric Point: 5.5653

>AT248770 WP_019076175.1 NZ_CP099381:3723761-3724135 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLVAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB A0A7L6U5G9

References