Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2395397..2396033 Replicon chromosome
Accession NZ_CP099381
Organism Citrobacter braakii strain RHB16-E2-C02

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NFJ84_RS11500 Protein ID WP_279265773.1
Coordinates 2395397..2395585 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ84_RS11505 Protein ID WP_131341011.1
Coordinates 2395617..2396033 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ84_RS11480 (NFJ84_11465) 2392176..2392406 - 231 WP_016156585.1 DUF2554 family protein -
NFJ84_RS11485 (NFJ84_11470) 2392596..2392721 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ84_RS11490 (NFJ84_11475) 2392721..2393731 - 1011 WP_141875205.1 cytochrome d ubiquinol oxidase subunit II -
NFJ84_RS11495 (NFJ84_11480) 2393731..2395134 - 1404 WP_016153156.1 cytochrome ubiquinol oxidase subunit I -
NFJ84_RS11500 (NFJ84_11485) 2395397..2395585 + 189 WP_279265773.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ84_RS11505 (NFJ84_11490) 2395617..2396033 + 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ84_RS11510 (NFJ84_11495) 2396126..2397535 + 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
NFJ84_RS11515 (NFJ84_11500) 2397865..2399010 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFJ84_RS11520 (NFJ84_11505) 2399027..2400043 + 1017 WP_016156582.1 ABC transporter ATP-binding protein -
NFJ84_RS11525 (NFJ84_11510) 2400044..2400988 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248765 WP_279265773.1 NZ_CP099381:2395397-2395585 [Citrobacter braakii]
VKQSEFRRWIESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT248765 WP_131341011.1 NZ_CP099381:2395617-2396033 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References