Detailed information of TA system
Overview
TA module
| Type | IV | Classification (family/domain) | yeeUV (cbtA-cbeA)/CbtA-CbeA |
| Location | 4364660..4365463 | Replicon | chromosome |
| Accession | NZ_CP099379 | ||
| Organism | Citrobacter braakii strain RHB16-SO-C07 | ||
Toxin (Protein)
| Gene name | yeeV | Uniprot ID | A0A6N6JYU3 |
| Locus tag | NFJ89_RS20830 | Protein ID | WP_024156451.1 |
| Coordinates | 4365083..4365463 (+) | Length | 127 a.a. |
Antitoxin (Protein)
| Gene name | yeeU | Uniprot ID | A0A5A9BSL8 |
| Locus tag | NFJ89_RS20825 | Protein ID | WP_038807908.1 |
| Coordinates | 4364660..4365025 (+) | Length | 122 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NFJ89_RS20800 (NFJ89_20800) | 4359744..4360355 | - | 612 | WP_094168984.1 | DUF2913 family protein | - |
| NFJ89_RS20805 (NFJ89_20805) | 4360830..4363028 | - | 2199 | WP_094168983.1 | DEAD/DEAH box helicase | - |
| NFJ89_RS20810 (NFJ89_20810) | 4363025..4363861 | - | 837 | Protein_4077 | DUF2791 family P-loop domain-containing protein | - |
| NFJ89_RS20815 (NFJ89_20815) | 4363924..4364403 | + | 480 | WP_024156448.1 | DNA repair protein RadC | - |
| NFJ89_RS20820 (NFJ89_20820) | 4364417..4364638 | + | 222 | WP_043017585.1 | DUF987 domain-containing protein | - |
| NFJ89_RS20825 (NFJ89_20825) | 4364660..4365025 | + | 366 | WP_038807908.1 | type IV toxin-antitoxin system YeeU family antitoxin | Antitoxin |
| NFJ89_RS20830 (NFJ89_20830) | 4365083..4365463 | + | 381 | WP_024156451.1 | TA system toxin CbtA family protein | Toxin |
| NFJ89_RS20835 (NFJ89_20835) | 4365460..4365951 | + | 492 | WP_024156452.1 | DUF5983 family protein | - |
| NFJ89_RS20840 (NFJ89_20840) | 4365981..4366177 | + | 197 | Protein_4083 | hypothetical protein | - |
| NFJ89_RS20845 (NFJ89_20845) | 4366260..4367108 | + | 849 | WP_137397940.1 | DUF4942 domain-containing protein | - |
| NFJ89_RS20850 (NFJ89_20850) | 4367608..4367703 | + | 96 | Protein_4085 | GNAT family N-acetyltransferase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Genomic island | - | - | 4336851..4365463 | 28612 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 127 a.a. Molecular weight: 14263.44 Da Isoelectric Point: 10.0919
>T248760 WP_024156451.1 NZ_CP099379:4365083-4365463 [Citrobacter braakii]
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS
MQTLSAIPKRKAPSRPTPVEIWQQLLTYLLKRHYGLSLSDTQFSDEEIITQYIDAGISLSDALNFLVEKSELVRIDRPGF
SIKHQSPFIGVIDILRARRATGLMQRNGYKRITLLIAGNAAQEQHS
Download Length: 381 bp
Antitoxin
Download Length: 122 a.a. Molecular weight: 13344.20 Da Isoelectric Point: 5.8705
>AT248760 WP_038807908.1 NZ_CP099379:4364660-4365025 [Citrobacter braakii]
MSNPIPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR
MSNPIPPVNHDVSEPWWGLKPGITPCFGARLVQEGNRLHYLADRASIAGVFSDADLRHLDQAFPVLLKQLELMLVSGELN
PCHQHCVTLYAKGLTCEADSLGSHGYIYTAIYPTPDDSITR
Download Length: 366 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6N6JYU3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5A9BSL8 |