Detailed information of TA system TA024876

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/Tad-HTH_37
• Location: 2369802..2370483
• Replicon: chromosome
• Accession: NC_014394
• Organism: Gallionella capsiferriformans ES-2

Toxin (Protein)

• Gene name: tad
• Uniprot ID: D9SIN3
• Locus tag: GALF_RS10915
• Protein ID: WP_013294120.1
• Coordinates: 2370115..2370483 (-)
• Length: 123 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: GALF_RS10910
• Protein ID: WP_013294119.1
• Coordinates: 2369802..2370122 (-)
• Length: 107 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GALF_RS10890	2365462..2366670	-	1209	WP_013294114.1	efflux RND transporter periplasmic adaptor subunit	-
GALF_RS10895	2366702..2367961	-	1260	WP_013294115.1	TolC family protein	-
GALF_RS15595	2368096..2368413	-	318	WP_190274075.1	hypothetical protein	-
GALF_RS10900	2369019..2369330	-	312	WP_013294117.1	hypothetical protein	-
GALF_RS10905	2369371..2369604	-	234	WP_013294118.1	DUF2798 domain-containing protein	-
GALF_RS10910	2369802..2370122	-	321	WP_013294119.1	helix-turn-helix domain-containing protein	Antitoxin
GALF_RS10915	2370115..2370483	-	369	WP_013294120.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
GALF_RS10920	2370696..2371268	-	573	WP_013294122.1	DUF3365 domain-containing protein	-
GALF_RS10925	2371332..2371523	-	192	WP_013294123.1	DUF2892 domain-containing protein	-
GALF_RS10930	2372076..2372570	-	495	WP_013294124.1	peptidylprolyl isomerase	-
GALF_RS10935	2372740..2373864	+	1125	WP_013294125.1	cupin domain-containing protein	-
GALF_RS10940	2373875..2374366	+	492	WP_013294126.1	hypothetical protein	-
GALF_RS15755	2374493..2374642	+	150	WP_190274076.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (17-110)

Antitoxin

• HigA2-like, helix-turn-helix domain (11-90)

Sequences

Toxin

Protein

• Length: 123 a.a.
• Molecular weight: 13524.55 Da
• Isoelectric Point: 9.4546

>T24876 WP_013294120.1 NC_014394:c2370483-2370115 [Gallionella capsiferriformans ES-2]
MNKVTVKPLEWVASSKKDLMSMPSDVVDVFGFALHVAQHGGKHLQAKPLKGFGSAGVLEVVEDDDGNTYRAVYTVRFGHA
VYVLHCFQKKSHKGIATPKQDIDLIRDRLKLAQQHAEGVKNE

Nucleotide

• Length: 369 bp

>T24876 NC_014394:c2370483-2370115 [Gallionella capsiferriformans ES-2]
ATGAATAAAGTCACGGTTAAGCCGCTAGAGTGGGTCGCATCCTCAAAAAAGGATTTGATGTCCATGCCGTCCGATGTCGT
GGATGTATTCGGGTTTGCGCTTCATGTGGCGCAGCATGGCGGGAAGCATTTACAAGCAAAACCATTGAAGGGTTTTGGAT
CGGCGGGTGTTCTTGAAGTTGTTGAAGATGATGACGGCAATACCTATCGAGCCGTCTACACAGTCCGGTTTGGTCATGCT
GTGTACGTGCTCCATTGTTTTCAAAAGAAATCCCATAAGGGTATCGCGACGCCCAAACAGGATATCGATCTGATTCGTGA
TAGGTTGAAATTGGCGCAGCAGCATGCGGAAGGAGTAAAAAATGAGTGA

Antitoxin

Protein

• Length: 107 a.a.
• Molecular weight: 11589.40 Da
• Isoelectric Point: 9.1183

>AT24876 WP_013294119.1 NC_014394:c2370122-2369802 [Gallionella capsiferriformans ES-2]
MSDIESGSNNVYADLGVPDAEEMWVKAQLATNIGEIIKRRKLTQVQAAELLGITQPKLSGLLRGQFRGISEAKLLECLTR
LGRDIQIVVKSAPRSRTEGHVSVVFA

Nucleotide

• Length: 321 bp

>AT24876 NC_014394:c2370122-2369802 [Gallionella capsiferriformans ES-2]
ATGAGTGATATTGAGTCTGGTAGCAACAATGTGTATGCCGACCTCGGGGTGCCTGATGCCGAAGAAATGTGGGTTAAAGC
CCAATTGGCCACTAATATTGGCGAGATCATTAAACGACGCAAATTAACGCAAGTTCAAGCCGCCGAATTGCTGGGTATCA
CGCAACCTAAACTGTCAGGTTTGTTGCGCGGTCAGTTTCGCGGTATTTCTGAAGCTAAGCTGTTGGAATGTCTCACGCGA
TTGGGGCGGGATATTCAGATTGTGGTTAAGTCTGCTCCGCGATCACGCACAGAAGGTCATGTGTCTGTTGTATTTGCATA
G

Structures

Toxin

• AlphaFold DB: D9SIN3