Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3528593..3529213 Replicon chromosome
Accession NZ_CP099379
Organism Citrobacter braakii strain RHB16-SO-C07

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFJ89_RS16925 Protein ID WP_002892050.1
Coordinates 3528995..3529213 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFJ89_RS16920 Protein ID WP_003021733.1
Coordinates 3528593..3528967 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ89_RS16910 (NFJ89_16910) 3523740..3524933 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFJ89_RS16915 (NFJ89_16915) 3524956..3528105 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFJ89_RS16920 (NFJ89_16920) 3528593..3528967 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFJ89_RS16925 (NFJ89_16925) 3528995..3529213 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFJ89_RS16930 (NFJ89_16930) 3529394..3529945 + 552 WP_016152072.1 maltose O-acetyltransferase -
NFJ89_RS16935 (NFJ89_16935) 3530062..3530532 + 471 WP_016152071.1 YlaC family protein -
NFJ89_RS16940 (NFJ89_16940) 3530611..3530751 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFJ89_RS16945 (NFJ89_16945) 3530753..3531013 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFJ89_RS16950 (NFJ89_16950) 3531202..3532755 + 1554 WP_047358017.1 EAL domain-containing protein -
NFJ89_RS16955 (NFJ89_16955) 3532807..3533160 - 354 WP_003831033.1 DUF1428 family protein -
NFJ89_RS16960 (NFJ89_16960) 3533225..3533854 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248758 WP_002892050.1 NZ_CP099379:3528995-3529213 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248758 WP_003021733.1 NZ_CP099379:3528593-3528967 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References