Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2299738..2300374 Replicon chromosome
Accession NZ_CP099379
Organism Citrobacter braakii strain RHB16-SO-C07

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag NFJ89_RS10960 Protein ID WP_049259794.1
Coordinates 2299738..2299926 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFJ89_RS10965 Protein ID WP_131341011.1
Coordinates 2299958..2300374 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ89_RS10940 (NFJ89_10940) 2296516..2296746 - 231 WP_016153158.1 DUF2554 family protein -
NFJ89_RS10945 (NFJ89_10945) 2296936..2297061 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFJ89_RS10950 (NFJ89_10950) 2297061..2298071 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFJ89_RS10955 (NFJ89_10955) 2298071..2299474 - 1404 WP_047417372.1 cytochrome ubiquinol oxidase subunit I -
NFJ89_RS10960 (NFJ89_10960) 2299738..2299926 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
NFJ89_RS10965 (NFJ89_10965) 2299958..2300374 + 417 WP_131341011.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFJ89_RS10970 (NFJ89_10970) 2300467..2301876 + 1410 WP_019076828.1 PLP-dependent aminotransferase family protein -
NFJ89_RS10975 (NFJ89_10975) 2302206..2303351 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFJ89_RS10980 (NFJ89_10980) 2303368..2304384 + 1017 WP_016156582.1 ABC transporter ATP-binding protein -
NFJ89_RS10985 (NFJ89_10985) 2304385..2305329 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248753 WP_049259794.1 NZ_CP099379:2299738-2299926 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15034.31 Da        Isoelectric Point: 4.7119

>AT248753 WP_131341011.1 NZ_CP099379:2299958-2300374 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGAEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References