Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 843776..844430 Replicon chromosome
Accession NZ_CP099379
Organism Citrobacter braakii strain RHB16-SO-C07

Toxin (Protein)


Gene name cptA Uniprot ID A0A7L6TYP6
Locus tag NFJ89_RS04125 Protein ID WP_047357821.1
Coordinates 844023..844430 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFJ89_RS04120 Protein ID WP_016154349.1
Coordinates 843776..844042 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFJ89_RS04095 (NFJ89_04095) 838989..840422 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
NFJ89_RS04100 (NFJ89_04100) 840543..841271 - 729 WP_008785744.1 MurR/RpiR family transcriptional regulator -
NFJ89_RS04105 (NFJ89_04105) 841324..841635 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFJ89_RS04110 (NFJ89_04110) 841799..842458 + 660 WP_016154351.1 hemolysin III family protein -
NFJ89_RS04115 (NFJ89_04115) 842538..843518 - 981 WP_047357823.1 tRNA-modifying protein YgfZ -
NFJ89_RS04120 (NFJ89_04120) 843776..844042 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFJ89_RS04125 (NFJ89_04125) 844023..844430 + 408 WP_047357821.1 protein YgfX Toxin
NFJ89_RS04130 (NFJ89_04130) 844531..845052 - 522 WP_016154347.1 flavodoxin FldB -
NFJ89_RS04135 (NFJ89_04135) 845166..846062 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFJ89_RS04140 (NFJ89_04140) 846086..846799 + 714 WP_047357820.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFJ89_RS04145 (NFJ89_04145) 846805..848538 + 1734 WP_065554323.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15878.67 Da        Isoelectric Point: 11.5023

>T248752 WP_047357821.1 NZ_CP099379:844023-844430 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQARQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248752 WP_016154349.1 NZ_CP099379:843776-844042 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7L6TYP6

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References