248751

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 4667986..4668602 Replicon chromosome
Accession NZ_CP099378
Organism Citrobacter braakii strain RHB21-E1-C04

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NFK10_RS22355 Protein ID WP_016155182.1
Coordinates 4667986..4668360 (-) Length 125 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID R8WIS4
Locus tag NFK10_RS22360 Protein ID WP_016155181.1
Coordinates 4668360..4668602 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK10_RS22340 (4665489) 4665489..4666391 + 903 WP_003028691.1 formate dehydrogenase O subunit beta -
NFK10_RS22345 (4666388) 4666388..4667023 + 636 WP_003028686.1 formate dehydrogenase cytochrome b556 subunit -
NFK10_RS22350 (4667020) 4667020..4667949 + 930 WP_003028685.1 formate dehydrogenase accessory protein FdhE -
NFK10_RS22355 (4667986) 4667986..4668360 - 375 WP_016155182.1 type II toxin-antitoxin system VapC family toxin Toxin
NFK10_RS22360 (4668360) 4668360..4668602 - 243 WP_016155181.1 CopG family transcriptional regulator Antitoxin
NFK10_RS22365 (4668808) 4668808..4669716 + 909 Protein_4368 alpha/beta hydrolase -
NFK10_RS22370 (4669781) 4669781..4670023 + 243 WP_016155179.1 type II toxin-antitoxin system ParD family antitoxin -
NFK10_RS22375 (4670016) 4670016..4670303 + 288 WP_016157876.1 type II toxin-antitoxin system RelE/ParE family toxin -
NFK10_RS22380 (4670309) 4670309..4671250 - 942 WP_003825286.1 fatty acid biosynthesis protein FabY -
NFK10_RS22385 (4671295) 4671295..4671732 - 438 WP_016157874.1 D-aminoacyl-tRNA deacylase -
NFK10_RS22390 (4671729) 4671729..4672601 - 873 WP_019077938.1 virulence factor BrkB family protein -
NFK10_RS22395 (4672595) 4672595..4673194 - 600 WP_016157873.1 glucose-1-phosphatase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(7-113)

Antitoxin

Ribbon-helix-helix protein, CopG

(13-47)


Sequences

Toxin        


Download         Length: 125 a.a.        Molecular weight: 13678.84 Da        Isoelectric Point: 8.5373

>T248751 WP_016155182.1 NZ_CP099378:c4668360-4667986 [Citrobacter braakii]
MVTGSALFDTNILIDLFSGRSEAKLAIETWPPQNAISLITWMELMVGAKKYHQESRTRVALGAFNVIGVSQDIAERSVSI
RQEYGMKLPDAIILATAQIHRLTLVTRNTRDFAGISGVVTPYTL

Download         Length: 375 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9437.72 Da        Isoelectric Point: 4.3331

>AT248751 WP_016155181.1 NZ_CP099378:c4668602-4668360 [Citrobacter braakii]
MMAGMDMGRILLDLSDEVIKRLDDLKVQRNLPRAELLREAVEQYLERQDQAETTISRALGLWQGCEEDGVDYQRKLREEW

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB R8WIS4

References