Detailed information of TA system TA024875

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relE-yefM/YoeB-RelB
• Location: 1267112..1267638
• Replicon: chromosome
• Accession: NC_014394
• Organism: Gallionella capsiferriformans ES-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: D9SFA3
• Locus tag: GALF_RS05880
• Protein ID: WP_013293139.1
• Coordinates: 1267112..1267375 (-)
• Length: 88 a.a.

Antitoxin (Protein)

• Gene name: yefM
• Uniprot ID: D9SFA4
• Locus tag: GALF_RS05885
• Protein ID: WP_013293140.1
• Coordinates: 1267378..1267638 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GALF_RS05865	1262271..1262882	+	612	WP_013293135.1	adenylyl-sulfate kinase	-
GALF_RS05870	1263563..1264726	+	1164	WP_013293137.1	methionine adenosyltransferase	-
GALF_RS05875	1265152..1267050	+	1899	WP_013293138.1	EAL domain-containing protein	-
GALF_RS05880	1267112..1267375	-	264	WP_013293139.1	Txe/YoeB family addiction module toxin	Toxin
GALF_RS05885	1267378..1267638	-	261	WP_013293140.1	type II toxin-antitoxin system prevent-host-death family antitoxin	Antitoxin
GALF_RS05890	1267807..1268142	-	336	WP_013293141.1	nucleotidyltransferase domain-containing protein	-
GALF_RS05895	1268362..1269891	+	1530	WP_013293142.1	fumarate hydratase	-
GALF_RS05900	1270229..1271944	+	1716	WP_013293143.1	DNA polymerase III subunit gamma/tau	-
GALF_RS05905	1271954..1272277	+	324	WP_041937993.1	YbaB/EbfC family nucleoid-associated protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin YoeB (6-85)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-75)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 10044.41 Da
• Isoelectric Point: 8.8867

>T24875 WP_013293139.1 NC_014394:c1267375-1267112 [Gallionella capsiferriformans ES-2]
MRAIQFVPDAWEAYLYWHGQDKKTLKRVNTLITAAARDPFAGIGKPEPLRGDLSGYWSRRIDDANRLVYRATDSELVIVA
CRFHYDS

Nucleotide

• Length: 264 bp

>T24875 NC_014394:c1267375-1267112 [Gallionella capsiferriformans ES-2]
ATGCGCGCCATCCAGTTTGTGCCGGACGCATGGGAGGCTTACCTGTATTGGCATGGGCAGGACAAGAAAACACTGAAGCG
GGTTAATACGCTGATTACCGCTGCTGCGCGCGATCCATTCGCCGGCATAGGCAAGCCGGAACCACTTCGTGGCGATTTAT
CTGGTTACTGGTCGCGGCGTATAGACGATGCGAATCGCCTGGTCTATCGCGCCACTGATTCCGAGCTGGTCATCGTGGCC
TGTCGTTTCCACTACGATAGTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9314.54 Da
• Isoelectric Point: 4.9849

>AT24875 WP_013293140.1 NC_014394:c1267638-1267378 [Gallionella capsiferriformans ES-2]
MKVVTYSYARNSLKSVLDGVVQDADVTIISRRDAEGDAVVMSLDSYNSMMETLHLTSNPANSAALAKAIAQDKAGQAQKR
QLLEIE

Nucleotide

• Length: 261 bp

>AT24875 NC_014394:c1267638-1267378 [Gallionella capsiferriformans ES-2]
ATGAAAGTTGTTACCTATTCGTATGCGCGTAATTCACTCAAATCCGTTTTGGATGGTGTTGTTCAGGATGCGGACGTAAC
CATAATCAGCCGGAGGGATGCCGAAGGGGATGCGGTGGTCATGTCACTGGATAGTTACAACAGCATGATGGAAACATTGC
ACCTGACAAGCAACCCGGCAAATTCTGCCGCATTGGCCAAGGCAATAGCGCAAGACAAAGCAGGCCAGGCACAGAAACGT
CAACTGCTTGAAATTGAATAG

Structures

Toxin

• AlphaFold DB: D9SFA3

Antitoxin

• AlphaFold DB: D9SFA4