Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3575115..3575735 Replicon chromosome
Accession NZ_CP099378
Organism Citrobacter braakii strain RHB21-E1-C04

Toxin (Protein)


Gene name Hha Uniprot ID R8WYV2
Locus tag NFK10_RS17395 Protein ID WP_002892050.1
Coordinates 3575517..3575735 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID R8WZW8
Locus tag NFK10_RS17390 Protein ID WP_003021733.1
Coordinates 3575115..3575489 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK10_RS17380 (3570262) 3570262..3571455 + 1194 WP_016152074.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NFK10_RS17385 (3571478) 3571478..3574627 + 3150 WP_016152073.1 efflux RND transporter permease AcrB -
NFK10_RS17390 (3575115) 3575115..3575489 + 375 WP_003021733.1 Hha toxicity modulator TomB Antitoxin
NFK10_RS17395 (3575517) 3575517..3575735 + 219 WP_002892050.1 HHA domain-containing protein Toxin
NFK10_RS17400 (3575916) 3575916..3576467 + 552 WP_016155874.1 maltose O-acetyltransferase -
NFK10_RS17405 (3576584) 3576584..3577054 + 471 WP_016152071.1 YlaC family protein -
NFK10_RS17410 (3577133) 3577133..3577273 - 141 WP_005125190.1 type B 50S ribosomal protein L36 -
NFK10_RS17415 (3577275) 3577275..3577535 - 261 WP_016152070.1 type B 50S ribosomal protein L31 -
NFK10_RS17420 (3577724) 3577724..3579277 + 1554 WP_016155873.1 EAL domain-containing protein -
NFK10_RS17425 (3579329) 3579329..3579682 - 354 WP_003831033.1 DUF1428 family protein -
NFK10_RS17430 (3579747) 3579747..3580376 - 630 WP_016155872.1 membrane protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T248747 WP_002892050.1 NZ_CP099378:3575517-3575735 [Citrobacter braakii]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14427.23 Da        Isoelectric Point: 5.5653

>AT248747 WP_003021733.1 NZ_CP099378:3575115-3575489 [Citrobacter braakii]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEQSNHGWVNDPTSATSLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2P8K6F2

Antitoxin

Source ID Structure
AlphaFold DB R8WZW8

References