Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2327787..2328423 Replicon chromosome
Accession NZ_CP099378
Organism Citrobacter braakii strain RHB21-E1-C04

Toxin (Protein)


Gene name hicA Uniprot ID A0A2I8S6E9
Locus tag NFK10_RS11230 Protein ID WP_049259794.1
Coordinates 2327787..2327975 (+) Length 63 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NFK10_RS11235 Protein ID WP_131382557.1
Coordinates 2328007..2328423 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK10_RS11210 (2324565) 2324565..2324795 - 231 WP_016156585.1 DUF2554 family protein -
NFK10_RS11215 (2324985) 2324985..2325110 - 126 WP_003020230.1 DUF2474 domain-containing protein -
NFK10_RS11220 (2325110) 2325110..2326120 - 1011 WP_016153157.1 cytochrome d ubiquinol oxidase subunit II -
NFK10_RS11225 (2326120) 2326120..2327523 - 1404 WP_016153156.1 cytochrome ubiquinol oxidase subunit I -
NFK10_RS11230 (2327787) 2327787..2327975 + 189 WP_049259794.1 type II toxin-antitoxin system HicA family toxin Toxin
NFK10_RS11235 (2328007) 2328007..2328423 + 417 WP_131382557.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NFK10_RS11240 (2328516) 2328516..2329925 + 1410 WP_016156583.1 PLP-dependent aminotransferase family protein -
NFK10_RS11245 (2330255) 2330255..2331400 + 1146 WP_016153154.1 ABC transporter substrate-binding protein -
NFK10_RS11250 (2331417) 2331417..2332433 + 1017 WP_016156582.1 ABC transporter ATP-binding protein -
NFK10_RS11255 (2332434) 2332434..2333378 + 945 WP_016153152.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-64)


Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7102.16 Da        Isoelectric Point: 11.5775

>T248742 WP_049259794.1 NZ_CP099378:2327787-2327975 [Citrobacter braakii]
VKQSEFRRWLESQGVAVTNGSNHLKLRYQGRRSVMPRHPGDEIKEALRKSILKQLGLQSSSI

Download         Length: 189 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15064.33 Da        Isoelectric Point: 4.7119

>AT248742 WP_131382557.1 NZ_CP099378:2328007-2328423 [Citrobacter braakii]
MRYPVNLIPAVEGGFVVSFPDIPEALTQGETRHGALQAAQSALVTAFEFYFDDNEPIPLPSAVGTEGDYVEIPLSIASKV
LLLNAFLESKITQQELANRIGRPKQEITRLFDLKHATKIDAVQIAARALGKELSVTML

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2I8S6E9

Antitoxin

Source ID Structure

References