Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 820691..821345 Replicon chromosome
Accession NZ_CP099378
Organism Citrobacter braakii strain RHB21-E1-C04

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFK10_RS04025 Protein ID WP_016154348.1
Coordinates 820938..821345 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFK10_RS04020 Protein ID WP_016154349.1
Coordinates 820691..820957 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK10_RS03995 (815904) 815904..817337 - 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -
NFK10_RS04000 (817458) 817458..818186 - 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFK10_RS04005 (818239) 818239..818550 + 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFK10_RS04010 (818714) 818714..819373 + 660 WP_016154351.1 hemolysin III family protein -
NFK10_RS04015 (819453) 819453..820433 - 981 WP_016157415.1 tRNA-modifying protein YgfZ -
NFK10_RS04020 (820691) 820691..820957 + 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFK10_RS04025 (820938) 820938..821345 + 408 WP_016154348.1 protein YgfX Toxin
NFK10_RS04030 (821446) 821446..821967 - 522 WP_016157414.1 flavodoxin FldB -
NFK10_RS04035 (822081) 822081..822977 + 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFK10_RS04040 (823001) 823001..823714 + 714 WP_016154345.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK10_RS04045 (823720) 823720..825453 + 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248741 WP_016154348.1 NZ_CP099378:820938-821345 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248741 WP_016154349.1 NZ_CP099378:820691-820957 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References