Detailed information of TA system TA024874

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/YafQ-RelB
• Location: 1057030..1057566
• Replicon: chromosome
• Accession: NC_014394
• Organism: Gallionella capsiferriformans ES-2

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: GALF_RS15505
• Protein ID: WP_150102655.1
• Coordinates: 1057393..1057566 (+)
• Length: 58 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: D9SET7
• Locus tag: GALF_RS05000
• Protein ID: WP_013292974.1
• Coordinates: 1057030..1057296 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
GALF_RS04980	1052423..1053583	+	1161	WP_013292970.1	hypothetical protein	-
GALF_RS04985	1053580..1054794	+	1215	WP_041937978.1	hypothetical protein	-
GALF_RS04990	1055166..1055429	+	264	WP_041938278.1	helix-turn-helix domain-containing protein	-
GALF_RS04995	1055426..1056736	+	1311	WP_013292973.1	HipA domain-containing protein	-
GALF_RS05000	1057030..1057296	+	267	WP_013292974.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
GALF_RS15505	1057393..1057566	+	174	WP_150102655.1	type II toxin-antitoxin system YafQ family toxin	Toxin
GALF_RS05005	1058131..1060041	+	1911	WP_013292975.1	diguanylate cyclase	-
GALF_RS05010	1060364..1060681	+	318	WP_013292976.1	flagellar transcriptional regulator FlhD	-
GALF_RS05015	1060692..1061240	+	549	WP_013292977.1	flagellar transcriptional regulator FlhC	-
GALF_RS05020	1061395..1062249	+	855	WP_013292978.1	flagellar motor stator protein MotA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	-	cheY / motA / cheY / flhA / flgC	866541..1107059	240518

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, YafQ-like toxin (4-57)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (6-84)

Sequences

Toxin

Protein

• Length: 58 a.a.
• Molecular weight: 6531.38 Da
• Isoelectric Point: 5.4164

>T24874 WP_150102655.1 NC_014394:1057393-1057566 [Gallionella capsiferriformans ES-2]
MLVDQPLPDNNRDHALSGDWTGYRECHVKPDILLIYLKPDLDTLRLAHFGSHSELFG

Nucleotide

• Length: 174 bp

>T24874 NC_014394:1057393-1057566 [Gallionella capsiferriformans ES-2]
CTGCTTGTCGATCAACCTTTGCCAGATAATAATCGTGATCACGCGTTGAGCGGTGATTGGACCGGATATAGAGAGTGTCA
TGTCAAGCCAGATATTCTGTTAATCTACCTCAAACCAGATTTAGACACTTTGCGGTTGGCGCATTTTGGCTCACATAGCG
AGCTATTCGGTTGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 9706.28 Da
• Isoelectric Point: 8.6143

>AT24874 WP_013292974.1 NC_014394:1057030-1057296 [Gallionella capsiferriformans ES-2]
MSIADTYVRARIDKVTKERATDALAAMGLSISDAIRLLMLRVADERRLPFDVKVPNATTRKAIVELESGKGKRFDSVDVL
MADLNADV

Nucleotide

• Length: 267 bp

>AT24874 NC_014394:1057030-1057296 [Gallionella capsiferriformans ES-2]
ATGAGTATTGCCGATACCTATGTTCGTGCTCGCATCGATAAGGTTACTAAAGAACGGGCCACTGACGCACTGGCAGCAAT
GGGTCTGTCAATATCGGATGCTATTCGCTTGCTGATGCTGCGTGTCGCCGATGAGCGTCGTTTGCCATTTGATGTAAAAG
TGCCGAACGCGACTACCCGTAAGGCTATTGTCGAGCTTGAATCAGGCAAGGGAAAACGTTTCGACAGCGTTGATGTACTG
ATGGCTGATTTGAATGCGGACGTTTGA

Structures

Antitoxin

• AlphaFold DB: D9SET7