Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4071004..4071658 Replicon chromosome
Accession NZ_CP099377
Organism Citrobacter braakii strain RHB23-SO-C01

Toxin (Protein)


Gene name cptA Uniprot ID R8WN60
Locus tag NFK19_RS19400 Protein ID WP_016154348.1
Coordinates 4071004..4071411 (-) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID R8WMJ6
Locus tag NFK19_RS19405 Protein ID WP_016154349.1
Coordinates 4071392..4071658 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NFK19_RS19380 (4066896) 4066896..4068629 - 1734 WP_016157413.1 single-stranded-DNA-specific exonuclease RecJ -
NFK19_RS19385 (4068635) 4068635..4069348 - 714 WP_279266595.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NFK19_RS19390 (4069372) 4069372..4070268 - 897 WP_016154346.1 site-specific tyrosine recombinase XerD -
NFK19_RS19395 (4070382) 4070382..4070903 + 522 WP_279266596.1 flavodoxin FldB -
NFK19_RS19400 (4071004) 4071004..4071411 - 408 WP_016154348.1 protein YgfX Toxin
NFK19_RS19405 (4071392) 4071392..4071658 - 267 WP_016154349.1 FAD assembly factor SdhE Antitoxin
NFK19_RS19410 (4071916) 4071916..4072896 + 981 WP_016154350.1 tRNA-modifying protein YgfZ -
NFK19_RS19415 (4072976) 4072976..4073635 - 660 WP_016154351.1 hemolysin III family protein -
NFK19_RS19420 (4073799) 4073799..4074110 - 312 WP_016154352.1 N(4)-acetylcytidine aminohydrolase -
NFK19_RS19425 (4074163) 4074163..4074891 + 729 WP_003838265.1 MurR/RpiR family transcriptional regulator -
NFK19_RS19430 (4075012) 4075012..4076445 + 1434 WP_016154353.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15850.66 Da        Isoelectric Point: 11.2845

>T248737 WP_016154348.1 NZ_CP099377:c4071411-4071004 [Citrobacter braakii]
VVQWQSDLRVSWRAQWLSLLIHGLVAVFILLMPWPLSYTPLWLVLLSLVVFDSVRSQRRINACQGEIRLLMDGRLRWQGQ
EWTIASAPWMVKTGMMLRLRSDAGKRQHLWLAADSMDDAEWRDLRRLILQQAKQG

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10557.10 Da        Isoelectric Point: 5.6375

>AT248737 WP_016154349.1 NZ_CP099377:c4071658-4071392 [Citrobacter braakii]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFIRLLECDDPDLFNWLMNHGKPADAQLEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R8WN60

Antitoxin

Source ID Structure
AlphaFold DB R8WMJ6

References